Detailed information of TA system TA036941

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2884772..2885616
• Replicon: chromosome
• Accession: NZ_AP023224
• Organism: Escherichia coli strain YJ1

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B1LJY4
• Locus tag: HXS59_RS13990
• Protein ID: WP_000854686.1
• Coordinates: 2884772..2885155 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E0J1S3
• Locus tag: HXS59_RS13995
• Protein ID: WP_001285602.1
• Coordinates: 2885236..2885616 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HXS59_RS13950	2879775..2880266	-	492	WP_001297187.1	DUF1097 domain-containing protein	-
HXS59_RS13955	2880368..2880922	-	555	WP_001001902.1	molecular chaperone YcdY	-
HXS59_RS13960	2880946..2881683	-	738	WP_000283664.1	zinc-binding phosphatase	-
HXS59_RS13965	2881738..2882676	-	939	WP_000351311.1	glyoxylate/hydroxypyruvate reductase GhrA	-
HXS59_RS13975	2883147..2883988	-	842	Protein_2736	DUF4942 domain-containing protein	-
HXS59_RS13980	2884073..2884270	-	198	WP_000839253.1	DUF957 domain-containing protein	-
HXS59_RS13985	2884287..2884775	-	489	WP_032180032.1	hypothetical protein	-
HXS59_RS13990	2884772..2885155	-	384	WP_000854686.1	TA system toxin CbtA family protein	Toxin
HXS59_RS13995	2885236..2885616	-	381	WP_001285602.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HXS59_RS14000	2885627..2886310	-	684	WP_000086768.1	hypothetical protein	-
HXS59_RS14005	2886329..2886550	-	222	WP_000692298.1	DUF987 domain-containing protein	-
HXS59_RS14010	2886613..2887089	-	477	WP_001186726.1	RadC family protein	-
HXS59_RS14015	2887105..2887332	-	228	Protein_2744	antirestriction protein	-
HXS59_RS14020	2887325..2889988	-	2664	Protein_2745	autotransporter adhesin Ag43	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-113)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14272.28 Da
• Isoelectric Point: 6.8614

>T36941 WP_000854686.1 NZ_AP023224:c2885155-2884772 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Nucleotide

• Length: 384 bp

>T36941 NZ_AP023224:c2885155-2884772 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13938.69 Da
• Isoelectric Point: 5.0823

>AT36941 WP_001285602.1 NZ_AP023224:c2885616-2885236 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT36941 NZ_AP023224:c2885616-2885236 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG