Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1870514..1871346 Replicon chromosome
Accession NZ_AP023224
Organism Escherichia coli strain YJ1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0Q2Y5N3
Locus tag HXS59_RS08945 Protein ID WP_001514886.1
Coordinates 1870514..1870888 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9IW59
Locus tag HXS59_RS08950 Protein ID WP_001360327.1
Coordinates 1870978..1871346 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXS59_RS08910 1866030..1866503 + 474 WP_001105385.1 DNA gyrase inhibitor SbmC -
HXS59_RS08915 1866702..1867760 + 1059 WP_032181141.1 FUSC family protein -
HXS59_RS08920 1867932..1868261 + 330 WP_000450409.1 DUF496 family protein -
HXS59_RS08925 1868362..1868544 - 183 WP_032181276.1 ethanolamine utilization protein -
HXS59_RS08930 1868998..1870026 - 1029 Protein_1747 IS110 family transposase -
HXS59_RS08935 1870185..1870298 - 114 WP_001161660.1 DUF957 domain-containing protein -
HXS59_RS08940 1870311..1870517 - 207 WP_000976829.1 hypothetical protein -
HXS59_RS08945 1870514..1870888 - 375 WP_001514886.1 TA system toxin CbtA family protein Toxin
HXS59_RS08950 1870978..1871346 - 369 WP_001360327.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HXS59_RS08955 1871509..1871730 - 222 WP_000692286.1 DUF987 domain-containing protein -
HXS59_RS08960 1871793..1872083 - 291 Protein_1753 hypothetical protein -
HXS59_RS08965 1872083..1872580 - 498 Protein_1754 AIDA repeat-containing protein -
HXS59_RS08970 1872952..1873824 - 873 WP_001069760.1 GTPase family protein -
HXS59_RS08975 1873909..1874826 - 918 WP_053911471.1 hypothetical protein -
HXS59_RS08980 1875658..1875855 - 198 WP_001329788.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13930.91 Da        Isoelectric Point: 7.2909

>T36931 WP_001514886.1 NZ_AP023224:c1870888-1870514 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T36931 NZ_AP023224:c1870888-1870514 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.34 Da        Isoelectric Point: 5.9598

>AT36931 WP_001360327.1 NZ_AP023224:c1871346-1870978 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT36931 NZ_AP023224:c1871346-1870978 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q2Y5N3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9IW59

References