Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3040923..3041758 Replicon chromosome
Accession NZ_AP023219
Organism Escherichia coli strain M505

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1C0Y405
Locus tag EPG46_RS14545 Protein ID WP_001774607.1
Coordinates 3041381..3041758 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M2U6P5
Locus tag EPG46_RS14540 Protein ID WP_001774606.1
Coordinates 3040923..3041291 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPG46_RS14500 3035955..3036635 + 681 WP_032082725.1 WYL domain-containing protein -
EPG46_RS14505 3036783..3037460 + 678 WP_001097305.1 hypothetical protein -
EPG46_RS14510 3037466..3037699 + 234 WP_126675705.1 DUF905 family protein -
EPG46_RS14515 3037798..3038616 + 819 WP_016238867.1 DUF945 domain-containing protein -
EPG46_RS14520 3038955..3039434 + 480 WP_032152717.1 antirestriction protein -
EPG46_RS14525 3039450..3039926 + 477 WP_001297237.1 RadC family protein -
EPG46_RS14530 3039989..3040210 + 222 WP_000692312.1 DUF987 domain-containing protein -
EPG46_RS14535 3040229..3040873 + 645 WP_001774605.1 hypothetical protein -
EPG46_RS14540 3040923..3041291 + 369 WP_001774606.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
EPG46_RS14545 3041381..3041758 + 378 WP_001774607.1 TA system toxin CbtA family protein Toxin
EPG46_RS14550 3041755..3042243 + 489 WP_001774608.1 hypothetical protein -
EPG46_RS14555 3042255..3042452 + 198 WP_032152719.1 DUF957 domain-containing protein -
EPG46_RS14560 3042537..3043379 + 843 WP_032152755.1 DUF4942 domain-containing protein -
EPG46_RS14565 3043661..3044197 - 537 WP_000942785.1 GspM family type II secretion system protein YghD -
EPG46_RS14570 3044199..3045377 - 1179 WP_000094991.1 type II secretion system protein GspL -
EPG46_RS14575 3045374..3046351 - 978 WP_000633209.1 type II secretion system minor pseudopilin GspK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3000060..3043512 43452


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14218.20 Da        Isoelectric Point: 7.8045

>T36904 WP_001774607.1 NZ_AP023219:3041381-3041758 [Escherichia coli]
MKTLPDTHVREASRCPPPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALIRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T36904 NZ_AP023219:3041381-3041758 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGCCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATACGGTGAACTTTCTCGTTGAAAAATACGCACTGATACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAACATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.31 Da        Isoelectric Point: 5.8746

>AT36904 WP_001774606.1 NZ_AP023219:3040923-3041291 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT36904 NZ_AP023219:3040923-3041291 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C0Y405

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2U6P5

References