Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1979613..1980444 Replicon chromosome
Accession NZ_AP023219
Organism Escherichia coli strain M505

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag EPG46_RS09530 Protein ID WP_000854814.1
Coordinates 1980070..1980444 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag EPG46_RS09525 Protein ID WP_001285585.1
Coordinates 1979613..1979981 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPG46_RS09495 1976613..1976971 + 359 Protein_1842 hypothetical protein -
EPG46_RS09500 1977050..1977283 + 234 WP_001119729.1 DUF905 family protein -
EPG46_RS09505 1977383..1978202 + 820 Protein_1844 DUF945 domain-containing protein -
EPG46_RS09510 1978284..1978763 + 480 WP_000860087.1 antirestriction protein -
EPG46_RS09515 1978779..1979255 + 477 WP_001186726.1 RadC family protein -
EPG46_RS09520 1979318..1979539 + 222 WP_000692323.1 DUF987 domain-containing protein -
EPG46_RS09525 1979613..1979981 + 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
EPG46_RS09530 1980070..1980444 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
EPG46_RS09535 1980441..1980635 + 195 WP_000988600.1 hypothetical protein -
EPG46_RS09540 1980648..1980761 + 114 WP_001161660.1 DUF957 domain-containing protein -
EPG46_RS09545 1981050..1981178 - 129 Protein_1852 transposase domain-containing protein -
EPG46_RS09550 1981250..1981432 + 183 WP_001016348.1 hypothetical protein -
EPG46_RS09555 1981533..1981862 - 330 WP_000450409.1 DUF496 family protein -
EPG46_RS09560 1982034..1983092 - 1059 WP_001200891.1 FUSC family protein -
EPG46_RS09565 1983289..1983762 - 474 WP_032224276.1 DNA gyrase inhibitor SbmC -
EPG46_RS09570 1983819..1985039 - 1221 Protein_1857 ISL3-like element ISKox3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1940304..1985039 44735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T36901 WP_000854814.1 NZ_AP023219:1980070-1980444 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T36901 NZ_AP023219:1980070-1980444 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT36901 WP_001285585.1 NZ_AP023219:1979613-1979981 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT36901 NZ_AP023219:1979613-1979981 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References