Detailed information of TA system TA036891

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 1372185..1372823
• Replicon: chromosome
• Accession: NZ_AP023219
• Organism: Escherichia coli strain M505

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0A6TXU8
• Locus tag: EPG46_RS06605
• Protein ID: WP_001447010.1
• Coordinates: 1372185..1372361 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EPG46_RS06610
• Protein ID: WP_001270286.1
• Coordinates: 1372407..1372823 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EPG46_RS06585	1367804..1369018	-	1215	WP_001326689.1	BenE family transporter YdcO	-
EPG46_RS06590	1369071..1369607	+	537	WP_000429155.1	DNA-binding transcriptional regulator SutR	-
EPG46_RS06595	1369680..1371641	+	1962	WP_001303492.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
EPG46_RS06600	1371733..1371963	-	231	WP_000494244.1	YncJ family protein	-
EPG46_RS06605	1372185..1372361	+	177	WP_001447010.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
EPG46_RS06610	1372407..1372823	+	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
EPG46_RS06615	1372902..1374308	+	1407	WP_000760626.1	PLP-dependent aminotransferase family protein	-
EPG46_RS06620	1374542..1375687	+	1146	WP_000047428.1	ABC transporter substrate-binding protein	-
EPG46_RS06625	1375705..1376718	+	1014	WP_000220395.1	ABC transporter ATP-binding protein	-
EPG46_RS06630	1376719..1377660	+	942	WP_001251304.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6779.86 Da
• Isoelectric Point: 11.2298

>T36891 WP_001447010.1 NZ_AP023219:1372185-1372361 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T36891 NZ_AP023219:1372185-1372361 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT36891 WP_001270286.1 NZ_AP023219:1372407-1372823 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT36891 NZ_AP023219:1372407-1372823 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A0A6TXU8