Detailed information of TA system TA036886

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 3106142..3106845
• Replicon: chromosome
• Accession: NZ_AP023213
• Organism: Geobacter bremensis strain R4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GEOBRER4_RS13580
• Protein ID: WP_185245332.1
• Coordinates: 3106426..3106845 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GEOBRER4_RS13575
• Protein ID: WP_185242754.1
• Coordinates: 3106142..3106423 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GEOBRER4_RS13555	3101774..3103399	-	1626	WP_185242750.1	ADP-ribosylglycohydrolase family protein	-
GEOBRER4_RS13560	3104066..3104527	+	462	WP_185242751.1	HNH endonuclease	-
GEOBRER4_RS13565	3104958..3105236	-	279	WP_185242752.1	hypothetical protein	-
GEOBRER4_RS13570	3105492..3105743	-	252	WP_185242753.1	hypothetical protein	-
GEOBRER4_RS13575	3106142..3106423	+	282	WP_185242754.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GEOBRER4_RS13580	3106426..3106845	+	420	WP_185245332.1	type II toxin-antitoxin system VapC family toxin	Toxin
GEOBRER4_RS13585	3107566..3110715	-	3150	WP_185242755.1	UvrD-helicase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3056379..3151324	94945

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (13-59)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15609.95 Da
• Isoelectric Point: 4.4938

>T36886 WP_185245332.1 NZ_AP023213:3106426-3106845 [Geobacter bremensis]
VKYLLDTCLVSELVKKEPDAKVVVWLDGCDEENLFLSVLTIGEIQKGISKLPDGERKETLQRWLEDDLTERFKGRILDVD
RDAAMAWGRLLGSSASRGETLPVMDSLIAATAINWGLVVVTRNVKDMGRCTESLFNPWE

Nucleotide

• Length: 420 bp

>T36886 NZ_AP023213:3106426-3106845 [Geobacter bremensis]
GTGAAGTATCTGCTGGATACCTGCCTGGTTTCAGAATTGGTCAAAAAAGAGCCAGACGCAAAGGTAGTGGTTTGGCTGGA
TGGCTGTGACGAAGAGAACCTGTTTTTAAGCGTATTGACCATAGGAGAGATCCAAAAGGGTATCAGCAAGTTACCGGATG
GTGAGCGCAAGGAAACTCTTCAGAGGTGGCTCGAAGACGACCTGACAGAGCGATTTAAGGGAAGGATCTTGGATGTGGAT
AGGGATGCAGCCATGGCGTGGGGTAGACTTTTGGGATCTTCAGCGAGCAGAGGCGAAACGCTTCCGGTAATGGACTCCTT
AATCGCCGCTACGGCTATCAATTGGGGGCTGGTTGTTGTGACGCGGAACGTCAAAGACATGGGACGATGCACGGAGAGTT
TATTTAATCCGTGGGAGTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10376.84 Da
• Isoelectric Point: 10.3135

>AT36886 WP_185242754.1 NZ_AP023213:3106142-3106423 [Geobacter bremensis]
MKNNKKHSPHVGSWQLQDAKNRLSQVVNSARSVGPQTITLRGEPAAVVISIEEYRKMVGKPKTSLSAFFAQSPLYNVELD
LTRSTDLPREVDL

Nucleotide

• Length: 282 bp

>AT36886 NZ_AP023213:3106142-3106423 [Geobacter bremensis]
ATGAAAAATAATAAAAAACATTCCCCACACGTCGGATCCTGGCAACTCCAGGATGCAAAGAACCGTCTGAGCCAGGTGGT
GAACTCGGCCCGATCCGTAGGCCCTCAGACCATCACTCTTCGCGGTGAACCGGCAGCGGTGGTCATCTCCATCGAGGAGT
ACCGGAAGATGGTTGGGAAGCCTAAAACATCTCTATCCGCCTTTTTTGCTCAGTCTCCACTTTATAATGTCGAACTCGAT
CTCACGCGCAGCACCGATCTGCCTCGGGAGGTGGATCTGTGA