36863

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1416363..1417017 Replicon chromosome
Accession NZ_AP023205
Organism Escherichia coli strain TUM18781

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag HUV20_RS06750 Protein ID WP_000244781.1
Coordinates 1416610..1417017 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag HUV20_RS06745 Protein ID WP_000354046.1
Coordinates 1416363..1416629 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUV20_RS06720 1411532..1412275 + 744 WP_000951951.1 SDR family oxidoreductase -
HUV20_RS06725 1412332..1413765 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
HUV20_RS06730 1413810..1414121 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
HUV20_RS06735 1414285..1414944 + 660 WP_000250274.1 hemolysin III family protein -
HUV20_RS06740 1415140..1416120 - 981 WP_000886095.1 tRNA-modifying protein YgfZ -
HUV20_RS06745 1416363..1416629 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
HUV20_RS06750 1416610..1417017 + 408 WP_000244781.1 protein YgfX Toxin
HUV20_RS06755 1417057..1417578 - 522 WP_001055874.1 flavodoxin FldB -
HUV20_RS06760 1417690..1418586 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HUV20_RS06765 1418611..1419321 + 711 WP_000715208.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HUV20_RS06770 1419327..1421060 + 1734 WP_000813218.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T36863 WP_000244781.1 NZ_AP023205:1416610-1417017 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T36863 NZ_AP023205:1416610-1417017 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT36863 WP_000354046.1 NZ_AP023205:1416363-1416629 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT36863 NZ_AP023205:1416363-1416629 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References