Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4384928..4385763 Replicon chromosome
Accession NZ_AP023197
Organism Escherichia coli strain TUM18780

Toxin (Protein)


Gene name yeeV Uniprot ID A0A5F1UHJ9
Locus tag HUV22_RS20695 Protein ID WP_039023548.1
Coordinates 4385386..4385763 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag HUV22_RS20690 Protein ID WP_001285607.1
Coordinates 4384928..4385296 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUV22_RS20655 4380820..4381500 + 681 WP_001282919.1 WYL domain-containing protein -
HUV22_RS20660 4381648..4382325 + 678 WP_001097301.1 hypothetical protein -
HUV22_RS20665 4382355..4382564 + 210 WP_174402685.1 DUF905 family protein -
HUV22_RS20670 4382654..4383472 + 819 WP_001175175.1 DUF945 domain-containing protein -
HUV22_RS20675 4383564..4384049 + 486 WP_000213722.1 antirestriction protein -
HUV22_RS20680 4384064..4384540 + 477 WP_001384029.1 RadC family protein -
HUV22_RS20685 4384627..4384848 + 222 WP_000692350.1 DUF987 domain-containing protein -
HUV22_RS20690 4384928..4385296 + 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUV22_RS20695 4385386..4385763 + 378 WP_039023548.1 TA system toxin CbtA family protein Toxin
HUV22_RS20700 4385760..4385930 + 171 Protein_4045 hypothetical protein -
HUV22_RS20705 4385985..4386182 + 198 WP_088172489.1 DUF957 domain-containing protein -
HUV22_RS20710 4386267..4387133 + 867 WP_039023551.1 DUF4942 domain-containing protein -
HUV22_RS20715 4387205..4387468 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
HUV22_RS20720 4387465..4387791 + 327 WP_000779482.1 type II toxin-antitoxin system RelE/ParE family toxin -
HUV22_RS20725 4388674..4390212 + 1539 WP_001187177.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4370011..4398025 28014


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14088.99 Da        Isoelectric Point: 7.3523

>T36847 WP_039023548.1 NZ_AP023197:4385386-4385763 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T36847 NZ_AP023197:4385386-4385763 [Escherichia coli]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT36847 WP_001285607.1 NZ_AP023197:4384928-4385296 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT36847 NZ_AP023197:4384928-4385296 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5F1UHJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References