Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4384898..4385733 Replicon chromosome
Accession NZ_AP023190
Organism Escherichia coli strain TUM18530

Toxin (Protein)


Gene name yeeV Uniprot ID A0A5F1UHJ9
Locus tag HUV24_RS20695 Protein ID WP_039023548.1
Coordinates 4385356..4385733 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag HUV24_RS20690 Protein ID WP_001285607.1
Coordinates 4384898..4385266 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUV24_RS20655 4380790..4381470 + 681 WP_001282919.1 WYL domain-containing protein -
HUV24_RS20660 4381618..4382295 + 678 WP_001097301.1 hypothetical protein -
HUV24_RS20665 4382325..4382534 + 210 WP_174402685.1 DUF905 family protein -
HUV24_RS20670 4382624..4383442 + 819 WP_001175175.1 DUF945 domain-containing protein -
HUV24_RS20675 4383534..4384019 + 486 WP_000213722.1 antirestriction protein -
HUV24_RS20680 4384034..4384510 + 477 WP_001384029.1 RadC family protein -
HUV24_RS20685 4384597..4384818 + 222 WP_000692350.1 DUF987 domain-containing protein -
HUV24_RS20690 4384898..4385266 + 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUV24_RS20695 4385356..4385733 + 378 WP_039023548.1 TA system toxin CbtA family protein Toxin
HUV24_RS20700 4385730..4385900 + 171 Protein_4045 hypothetical protein -
HUV24_RS20705 4385955..4386152 + 198 WP_088172489.1 DUF957 domain-containing protein -
HUV24_RS20710 4386237..4387103 + 867 WP_039023551.1 DUF4942 domain-containing protein -
HUV24_RS20715 4387175..4387438 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
HUV24_RS20720 4387435..4387761 + 327 WP_000779482.1 type II toxin-antitoxin system RelE/ParE family toxin -
HUV24_RS20725 4388644..4390182 + 1539 WP_001187177.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4373276..4397995 24719


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14088.99 Da        Isoelectric Point: 7.3523

>T36813 WP_039023548.1 NZ_AP023190:4385356-4385733 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T36813 NZ_AP023190:4385356-4385733 [Escherichia coli]
ATGAACACATTACCCGATACACACGTACGGGAGGCATCGCATTGCCAGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACGCTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT36813 WP_001285607.1 NZ_AP023190:4384898-4385266 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT36813 NZ_AP023190:4384898-4385266 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAAGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5F1UHJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References