Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 4620224..4620821 Replicon chromosome
Accession NZ_AP023189
Organism Pseudomonas sp. TUM18999

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HSX14_RS20905 Protein ID WP_173177964.1
Coordinates 4620224..4620532 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HSX14_RS20910 Protein ID WP_173177962.1
Coordinates 4620525..4620821 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSX14_RS20890 4616237..4617874 - 1638 WP_173177970.1 AMP-binding protein -
HSX14_RS20895 4617987..4618817 - 831 WP_173177968.1 amidohydrolase family protein -
HSX14_RS20900 4618885..4620024 - 1140 WP_173177966.1 acyl-CoA dehydrogenase family protein -
HSX14_RS20905 4620224..4620532 + 309 WP_173177964.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HSX14_RS20910 4620525..4620821 + 297 WP_173177962.1 putative addiction module antidote protein Antitoxin
HSX14_RS20915 4620912..4622198 - 1287 WP_111262038.1 dicarboxylate/amino acid:cation symporter -
HSX14_RS20920 4622522..4623520 + 999 WP_173177960.1 AraC family transcriptional regulator -
HSX14_RS20925 4623554..4623871 - 318 WP_173177958.1 antibiotic biosynthesis monooxygenase -
HSX14_RS20930 4624036..4624620 + 585 WP_173177956.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11383.01 Da        Isoelectric Point: 9.0953

>T36790 WP_173177964.1 NZ_AP023189:4620224-4620532 [Pseudomonas sp. TUM18999]
MIEVLQSREFATWLNHLSDGKARARILARIDRMADGHLGDVAPIGEGLSEARLHFGPGYRLYFLQRGQLLIVLLCGGDKG
SQGRDIGHARRIAAAWKEQHHD

Download         Length: 309 bp

>T36790 NZ_AP023189:4620224-4620532 [Pseudomonas sp. TUM18999]
ATGATCGAGGTCCTCCAGAGCAGGGAGTTCGCCACCTGGCTGAACCACCTGAGCGACGGCAAGGCCAGGGCACGGATACT
GGCTCGCATCGACCGCATGGCCGACGGCCACCTGGGGGACGTCGCACCGATAGGCGAGGGCCTCAGCGAAGCCCGGCTCC
ACTTCGGCCCCGGCTATCGGCTCTACTTTCTCCAGCGCGGCCAGCTCCTGATCGTCCTCCTTTGCGGTGGCGACAAGGGC
AGCCAGGGGCGAGATATCGGACACGCCAGGCGCATCGCCGCAGCCTGGAAGGAGCAACACCATGACTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10732.01 Da        Isoelectric Point: 4.6533

>AT36790 WP_173177962.1 NZ_AP023189:4620525-4620821 [Pseudomonas sp. TUM18999]
MTEDFSRWDSADYLRSEEDMANYLDACIEEAGDDPAFIAKALGTLARAKGMTQVARDTGLSRESLYRALSGEGNPEFGTI
LKVLRALGLQLHASPARH

Download         Length: 297 bp

>AT36790 NZ_AP023189:4620525-4620821 [Pseudomonas sp. TUM18999]
ATGACTGAAGACTTTTCCCGCTGGGACTCCGCCGACTACCTGCGTAGCGAGGAAGACATGGCCAACTACCTGGATGCCTG
CATCGAGGAAGCCGGCGACGATCCCGCCTTCATCGCCAAGGCCCTCGGCACCCTCGCCCGCGCCAAGGGCATGACCCAGG
TCGCCCGCGACACCGGCCTCTCGCGCGAGAGCCTGTACCGCGCGCTGTCCGGCGAGGGCAATCCCGAGTTCGGCACCATC
CTCAAGGTCCTCAGGGCACTCGGCCTGCAACTGCATGCCAGCCCCGCCCGCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References