Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 4103492..4104125 Replicon chromosome
Accession NZ_AP023189
Organism Pseudomonas sp. TUM18999

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HSX14_RS18490 Protein ID WP_197970198.1
Coordinates 4103492..4103863 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HSX14_RS18495 Protein ID WP_173180255.1
Coordinates 4103889..4104125 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSX14_RS18455 4098630..4098902 + 273 WP_021217973.1 DUF2282 domain-containing protein -
HSX14_RS18460 4098919..4099758 + 840 WP_173180248.1 DUF692 domain-containing protein -
HSX14_RS18465 4099755..4100540 + 786 WP_173180249.1 DNA-binding domain-containing protein -
HSX14_RS18470 4100553..4101017 + 465 WP_173180250.1 DoxX family protein -
HSX14_RS18475 4101025..4101732 - 708 WP_173180251.1 chalcone isomerase family protein -
HSX14_RS18480 4101695..4102591 - 897 WP_173180252.1 alpha/beta hydrolase -
HSX14_RS18485 4102716..4103483 + 768 WP_173180253.1 DUF2092 domain-containing protein -
HSX14_RS18490 4103492..4103863 - 372 WP_197970198.1 PIN domain-containing protein Toxin
HSX14_RS18495 4103889..4104125 - 237 WP_173180255.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HSX14_RS18500 4104247..4104897 + 651 WP_173180256.1 hypothetical protein -
HSX14_RS18505 4105078..4105992 - 915 WP_173180257.1 LysR family transcriptional regulator -
HSX14_RS18510 4106152..4107489 + 1338 WP_173180258.1 purine permease -
HSX14_RS18515 4107529..4108035 + 507 WP_173180259.1 nucleoside deaminase -
HSX14_RS18520 4108032..4108388 + 357 WP_173180260.1 hydroxyisourate hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-105)

Antitoxin

SpoVT-AbrB domain

(5-43)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13540.76 Da        Isoelectric Point: 7.1890

>T36789 WP_197970198.1 NZ_AP023189:c4103863-4103492 [Pseudomonas sp. TUM18999]
VLLYLLSADPAKADAAEALLAKRPTISVQVLNEVASVCSRKLRMSWDEIGRFLELVQGFCRVVPVTLEVHRQARELADRY
RLSFYDACIAAAALVAGCSTLHSEDMHSGLLLDGRLRVLNPFG

Download         Length: 372 bp

>T36789 NZ_AP023189:c4103863-4103492 [Pseudomonas sp. TUM18999]
GTGCTGCTCTATCTGCTGTCCGCCGACCCGGCCAAGGCGGATGCCGCCGAGGCACTGCTGGCGAAGAGACCGACGATCAG
TGTGCAGGTTCTCAATGAGGTGGCCAGCGTCTGCTCCCGCAAGTTGAGGATGAGCTGGGATGAGATCGGCCGTTTCCTGG
AGCTGGTGCAAGGCTTCTGTCGCGTCGTACCGGTGACGCTGGAGGTCCACCGGCAGGCGCGTGAGCTGGCTGATCGCTAC
AGGCTGTCTTTCTACGATGCCTGTATCGCCGCCGCTGCGCTTGTCGCGGGCTGCTCGACCCTCCACAGCGAAGACATGCA
CTCGGGGTTGCTCCTCGATGGGCGTTTGCGGGTGCTGAATCCGTTCGGCTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8769.90 Da        Isoelectric Point: 4.8660

>AT36789 WP_173180255.1 NZ_AP023189:c4104125-4103889 [Pseudomonas sp. TUM18999]
MQVAKWGNSLAVRIPASVVEALELKEGDDIEILIEGDRTFAISKRPDDEGRLARLRAFRGKLPADFRFNRDEAAGRED

Download         Length: 237 bp

>AT36789 NZ_AP023189:c4104125-4103889 [Pseudomonas sp. TUM18999]
ATGCAAGTCGCGAAGTGGGGAAACAGCCTGGCGGTGCGTATACCGGCGAGCGTGGTCGAGGCGCTGGAACTGAAGGAGGG
CGACGATATCGAGATACTGATCGAGGGTGATCGCACCTTCGCCATCAGCAAGAGGCCTGACGATGAGGGGCGGCTTGCGC
GGCTACGGGCGTTTCGCGGCAAGCTGCCGGCGGATTTCCGTTTCAACCGCGATGAGGCCGCTGGCCGTGAGGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References