Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2727962..2729215 Replicon chromosome
Accession NZ_AP023189
Organism Pseudomonas sp. TUM18999

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HSX14_RS12525 Protein ID WP_173174518.1
Coordinates 2728631..2729215 (+) Length 195 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HSX14_RS12520 Protein ID WP_173174520.1
Coordinates 2727962..2728519 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HSX14_RS12500 2723528..2724139 + 612 WP_173174526.1 LysE family translocator -
HSX14_RS12505 2724142..2726193 - 2052 WP_173174571.1 PAS domain S-box protein -
HSX14_RS12510 2726415..2727164 + 750 WP_173174524.1 NAD-dependent deacylase -
HSX14_RS12515 2727191..2727706 - 516 WP_173174522.1 thioredoxin family protein -
HSX14_RS12520 2727962..2728519 + 558 WP_173174520.1 helix-turn-helix domain-containing protein Antitoxin
HSX14_RS12525 2728631..2729215 + 585 WP_173174518.1 HD domain-containing protein Toxin
HSX14_RS12530 2729433..2729810 + 378 WP_173174569.1 cytochrome c -
HSX14_RS12535 2729834..2729974 - 141 WP_173174516.1 DUF2256 domain-containing protein -
HSX14_RS12540 2729971..2731515 - 1545 WP_173174513.1 cryptochrome/photolyase family protein -
HSX14_RS12545 2731509..2731814 - 306 WP_173174511.1 metal ABC transporter ATPase -
HSX14_RS12550 2731845..2732381 - 537 WP_173174509.1 DUF3833 domain-containing protein -
HSX14_RS12555 2732393..2732944 - 552 WP_173174507.1 chalcone isomerase family protein -
HSX14_RS12560 2733174..2734130 + 957 WP_173174505.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-191)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-67)


Sequences

Toxin        


Download         Length: 195 a.a.        Molecular weight: 21659.34 Da        Isoelectric Point: 4.7781

>T36788 WP_173174518.1 NZ_AP023189:2728631-2729215 [Pseudomonas sp. TUM18999]
MNIDTIRARLDFLREAERLKDVLRSAHTSSGRVESTAEHSWRLCLMAITFADELAGLDLLRVLKMCVVHDLGEAIHGDIP
AVEQGGHPDKGAQEREDLLTLTRTLDDGLRGEILALWDDYENAASPEALAVKALDKLETLLQHTQGANPEDFDYAFNLGY
GRRYTSGEPLFAAIRAQLDEDTRRRMEARASAAR

Download         Length: 585 bp

>T36788 NZ_AP023189:2728631-2729215 [Pseudomonas sp. TUM18999]
ATGAACATCGACACCATCAGGGCGCGGCTCGACTTCCTGCGTGAGGCGGAGCGCCTCAAGGATGTGCTGCGCAGCGCCCA
CACCTCTTCCGGGCGGGTGGAAAGCACCGCCGAGCACAGCTGGCGCCTGTGCCTGATGGCCATCACCTTCGCCGACGAGC
TGGCCGGGCTCGACCTGCTGCGGGTGCTGAAGATGTGCGTGGTGCACGACCTGGGCGAGGCCATCCATGGCGACATCCCC
GCCGTCGAGCAGGGCGGCCATCCCGACAAGGGGGCCCAGGAGCGCGAGGACCTGCTGACCCTCACCCGCACCCTGGACGA
TGGGCTGCGCGGGGAGATCCTCGCGCTGTGGGACGACTACGAGAACGCCGCCTCCCCCGAGGCGCTGGCGGTCAAGGCGC
TGGACAAGCTGGAGACCCTGCTGCAGCACACCCAGGGCGCCAACCCGGAGGACTTCGACTACGCCTTCAACCTCGGCTAC
GGGCGCCGCTACACCAGCGGCGAACCGCTGTTCGCGGCCATCCGTGCACAGCTGGACGAGGACACGAGGCGGCGGATGGA
GGCGCGGGCGAGCGCGGCTCGCTGA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20308.48 Da        Isoelectric Point: 9.4760

>AT36788 WP_173174520.1 NZ_AP023189:2727962-2728519 [Pseudomonas sp. TUM18999]
MHDSLPKPVSLGLALRRWRLLHRVKQAHAAQLFGVAQSTISRWESGAQAMEPAERARVERVLGARLEAAADQALARLVGD
SPRAVHLVCDLSHRLLACSALRAAEFSVPLSELMGRSLWRYATPEIVRQEAALDALGWRDVLMPPALEFGSGSNESAIVP
IRQGLCRWTRMTLSDGTAARLVETL

Download         Length: 558 bp

>AT36788 NZ_AP023189:2727962-2728519 [Pseudomonas sp. TUM18999]
ATGCACGACAGCCTCCCGAAACCGGTCTCGCTCGGCCTCGCGTTGCGCCGTTGGCGCCTGCTGCACCGGGTGAAGCAGGC
CCACGCCGCGCAGCTGTTCGGCGTCGCCCAGTCGACCATCTCGCGCTGGGAAAGCGGGGCGCAGGCGATGGAACCGGCCG
AGCGCGCGCGGGTGGAGCGGGTGCTTGGCGCCCGGCTGGAGGCGGCGGCCGACCAGGCCCTGGCGCGGCTGGTGGGCGAC
AGCCCGCGCGCGGTGCACCTGGTCTGCGACCTGAGCCATCGCCTGCTGGCCTGTTCCGCCCTGCGCGCCGCCGAATTCAG
CGTGCCCCTCTCCGAGCTGATGGGCCGCTCGCTGTGGCGCTATGCGACGCCGGAGATCGTGCGCCAGGAAGCCGCGCTGG
ACGCCCTGGGCTGGCGCGACGTGCTGATGCCGCCGGCGCTGGAGTTCGGCAGCGGCAGCAACGAATCCGCCATCGTGCCG
ATCCGCCAGGGCCTGTGCCGCTGGACGCGCATGACGCTTTCCGACGGCACCGCCGCGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References