Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 2123764..2124323 | Replicon | chromosome |
| Accession | NZ_AP023187 | ||
| Organism | Vibrio alginolyticus strain HLBS-07 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A2I3C6F2 |
| Locus tag | M2042_RS10250 | Protein ID | WP_005377065.1 |
| Coordinates | 2124045..2124323 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A2I3C6F3 |
| Locus tag | M2042_RS10245 | Protein ID | WP_005487956.1 |
| Coordinates | 2123764..2124048 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M2042_RS10185 | 2118835..2118924 | - | 90 | WP_243190269.1 | DUF3265 domain-containing protein | - |
| M2042_RS10190 (HLBS07_19590) | 2118994..2119227 | - | 234 | WP_005377029.1 | hypothetical protein | - |
| M2042_RS10195 | 2119257..2119349 | - | 93 | WP_199267706.1 | DUF3265 domain-containing protein | - |
| M2042_RS10200 (HLBS07_19600) | 2119369..2120001 | - | 633 | WP_158156607.1 | hypothetical protein | - |
| M2042_RS10205 | 2120082..2120211 | - | 130 | Protein_1991 | DUF3265 domain-containing protein | - |
| M2042_RS10210 | 2120630..2120719 | - | 90 | WP_079390649.1 | DUF3265 domain-containing protein | - |
| M2042_RS10215 (HLBS07_19610) | 2120966..2121115 | - | 150 | WP_199266769.1 | hypothetical protein | - |
| M2042_RS10220 (HLBS07_19620) | 2121348..2121890 | - | 543 | WP_033907393.1 | GNAT family N-acetyltransferase | - |
| M2042_RS10225 | 2121923..2122015 | - | 93 | WP_079380089.1 | DUF3265 domain-containing protein | - |
| M2042_RS10230 (HLBS07_19630) | 2122041..2122508 | - | 468 | WP_062866184.1 | cold shock domain-containing protein | - |
| M2042_RS10235 | 2122547..2122676 | - | 130 | Protein_1997 | DUF3265 domain-containing protein | - |
| M2042_RS10240 (HLBS07_19640) | 2123357..2123536 | + | 180 | WP_248525396.1 | hypothetical protein | - |
| M2042_RS10245 (HLBS07_19650) | 2123764..2124048 | + | 285 | WP_005487956.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| M2042_RS10250 (HLBS07_19660) | 2124045..2124323 | + | 279 | WP_005377065.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| M2042_RS10255 (HLBS07_19670) | 2124469..2124894 | - | 426 | WP_248525300.1 | hypothetical protein | - |
| M2042_RS10260 | 2124923..2125012 | - | 90 | WP_196298333.1 | DUF3265 domain-containing protein | - |
| M2042_RS10265 (HLBS07_19680) | 2125030..2125599 | - | 570 | WP_248525301.1 | hypothetical protein | - |
| M2042_RS10270 | 2126170..2126260 | - | 91 | Protein_2004 | DUF3265 domain-containing protein | - |
| M2042_RS10275 (HLBS07_19710) | 2126290..2126739 | - | 450 | WP_248525302.1 | GNAT family N-acetyltransferase | - |
| M2042_RS10280 | 2126769..2126861 | - | 93 | WP_197064557.1 | DUF3265 domain-containing protein | - |
| M2042_RS10285 (HLBS07_19720) | 2126891..2127361 | - | 471 | WP_050905177.1 | GNAT family N-acetyltransferase | - |
| M2042_RS10290 (HLBS07_19730) | 2127518..2127967 | - | 450 | WP_053304455.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 2005402..2144022 | 138620 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10905.60 Da Isoelectric Point: 4.3430
>T36786 WP_005377065.1 NZ_AP023187:2124045-2124323 [Vibrio alginolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIISYWVEGDIIRVM
RVLHQKQKFPTD
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIISYWVEGDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T36786 NZ_AP023187:2124045-2124323 [Vibrio alginolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGCGTACAACGAGATGGTA
TCCGCGGACGATTACTCATTATTCCTGAGATTTCGATGATTATCTCTTACTGGGTCGAGGGAGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGCGTACAACGAGATGGTA
TCCGCGGACGATTACTCATTATTCCTGAGATTTCGATGATTATCTCTTACTGGGTCGAGGGAGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11082.40 Da Isoelectric Point: 9.2167
>AT36786 WP_005487956.1 NZ_AP023187:2123764-2124048 [Vibrio alginolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQNAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQNAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT36786 NZ_AP023187:2123764-2124048 [Vibrio alginolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAGCAACTTGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAGTCCGTTTTCGTTGAGCACCAAAATGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAGCAACTTGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAGTCCGTTTTCGTTGAGCACCAAAATGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I3C6F2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I3C6F3 |