Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 2032829..2033388 | Replicon | chromosome |
| Accession | NZ_AP023187 | ||
| Organism | Vibrio alginolyticus strain HLBS-07 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A347UR22 |
| Locus tag | M2042_RS09325 | Protein ID | WP_005398411.1 |
| Coordinates | 2033110..2033388 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR21 |
| Locus tag | M2042_RS09320 | Protein ID | WP_005398409.1 |
| Coordinates | 2032829..2033113 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M2042_RS09275 | 2028346..2028435 | - | 90 | WP_077345960.1 | DUF3265 domain-containing protein | - |
| M2042_RS09280 (HLBS07_18450) | 2029019..2029399 | - | 381 | WP_104979310.1 | STAS/SEC14 domain-containing protein | - |
| M2042_RS09285 (HLBS07_18460) | 2029623..2029913 | - | 291 | WP_042523463.1 | hypothetical protein | - |
| M2042_RS09290 (HLBS07_18470) | 2030060..2030458 | - | 399 | WP_042524338.1 | SMI1/KNR4 family protein | - |
| M2042_RS09295 (HLBS07_18480) | 2030576..2031535 | - | 960 | WP_104975411.1 | phosphotransferase | - |
| M2042_RS09300 | 2031616..2031681 | - | 66 | Protein_1810 | DUF3265 domain-containing protein | - |
| M2042_RS09305 (HLBS07_18490) | 2031709..2032095 | - | 387 | WP_104979311.1 | hypothetical protein | - |
| M2042_RS09310 (HLBS07_18500) | 2032092..2032508 | - | 417 | WP_104979313.1 | hypothetical protein | - |
| M2042_RS09315 | 2032660..2032752 | - | 93 | WP_104975412.1 | DUF3265 domain-containing protein | - |
| M2042_RS09320 (HLBS07_18510) | 2032829..2033113 | + | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| M2042_RS09325 (HLBS07_18520) | 2033110..2033388 | + | 279 | WP_005398411.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| M2042_RS09330 (HLBS07_18530) | 2033525..2034061 | - | 537 | WP_104975413.1 | nucleotidyltransferase family protein | - |
| M2042_RS09335 (HLBS07_18540) | 2034206..2034754 | - | 549 | WP_104979317.1 | hypothetical protein | - |
| M2042_RS09340 (HLBS07_18550) | 2034904..2035215 | - | 312 | WP_136977026.1 | hypothetical protein | - |
| M2042_RS09345 (HLBS07_18560) | 2035357..2035866 | - | 510 | WP_104979320.1 | DUF4145 domain-containing protein | - |
| M2042_RS09350 | 2035893..2035982 | - | 90 | WP_080262357.1 | DUF3265 domain-containing protein | - |
| M2042_RS09355 | 2036443..2036535 | - | 93 | WP_115386054.1 | DUF3265 domain-containing protein | - |
| M2042_RS09360 (HLBS07_18570) | 2036550..2037548 | - | 999 | WP_104979324.1 | alpha/beta fold hydrolase | - |
| M2042_RS09365 | 2038069..2038159 | - | 91 | Protein_1823 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1995838..2106087 | 110249 | |
| - | inside | Integron | - | - | 2005402..2144022 | 138620 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10891.57 Da Isoelectric Point: 4.3430
>T36785 WP_005398411.1 NZ_AP023187:2033110-2033388 [Vibrio alginolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T36785 NZ_AP023187:2033110-2033388 [Vibrio alginolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTTAACCCTGATGCGGC
AGAAAAAACTGACAACCTTATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAAAAACAAAAATTTCCTACAGATTGA
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTTAACCCTGATGCGGC
AGAAAAAACTGACAACCTTATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAAAAACAAAAATTTCCTACAGATTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11069.40 Da Isoelectric Point: 9.2167
>AT36785 WP_005398409.1 NZ_AP023187:2032829-2033113 [Vibrio alginolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT36785 NZ_AP023187:2032829-2033113 [Vibrio alginolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR22 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR21 |