Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1331250..1331778 Replicon chromosome
Accession NZ_AP023185
Organism Vibrio alginolyticus strain YZOS-03

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag YZOS03_RS06550 Protein ID WP_005377002.1
Coordinates 1331250..1331540 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag YZOS03_RS06555 Protein ID WP_005377003.1
Coordinates 1331530..1331778 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YZOS03_RS06485 (YZOS03_11660) 1326802..1327182 + 381 WP_213987839.1 DUF4087 domain-containing protein -
YZOS03_RS06490 1327209..1327298 + 90 WP_109170471.1 DUF3265 domain-containing protein -
YZOS03_RS06495 (YZOS03_11670) 1327342..1327824 + 483 WP_017821432.1 hypothetical protein -
YZOS03_RS06500 (YZOS03_11680) 1327963..1328319 + 357 WP_017633715.1 cell envelope integrity protein TolA -
YZOS03_RS06505 1328346..1328438 + 93 WP_196363379.1 DUF3265 domain-containing protein -
YZOS03_RS06510 (YZOS03_11690) 1328471..1329013 + 543 WP_206949760.1 N-acetyltransferase -
YZOS03_RS06515 1329031..1329120 + 90 WP_073514058.1 DUF3265 domain-containing protein -
YZOS03_RS06520 (YZOS03_11700) 1329149..1329427 - 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
YZOS03_RS06525 (YZOS03_11710) 1329424..1329708 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
YZOS03_RS06530 (YZOS03_11720) 1329910..1330386 + 477 WP_024702472.1 GNAT family N-acetyltransferase -
YZOS03_RS06535 1330401..1330493 + 93 WP_080540751.1 DUF3265 domain-containing protein -
YZOS03_RS06540 (YZOS03_11730) 1330531..1331124 + 594 WP_213987838.1 hypothetical protein -
YZOS03_RS06545 1331142..1331231 + 90 WP_206949765.1 DUF3265 domain-containing protein -
YZOS03_RS06550 (YZOS03_11740) 1331250..1331540 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
YZOS03_RS06555 (YZOS03_11750) 1331530..1331778 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
YZOS03_RS06560 1331835..1331921 + 87 WP_225492314.1 DUF3265 domain-containing protein -
YZOS03_RS06565 (YZOS03_11760) 1331971..1332480 + 510 WP_206949758.1 AAA family ATPase -
YZOS03_RS06570 (YZOS03_11770) 1332615..1333376 + 762 WP_031852916.1 DUF4145 domain-containing protein -
YZOS03_RS06575 1333363..1333494 + 132 WP_248475487.1 DUF3265 domain-containing protein -
YZOS03_RS06580 (YZOS03_11780) 1333532..1334230 + 699 WP_191118274.1 hypothetical protein -
YZOS03_RS06585 1334253..1334345 + 93 WP_199479330.1 DUF3265 domain-containing protein -
YZOS03_RS06590 (YZOS03_11790) 1334380..1334961 + 582 WP_045402133.1 hypothetical protein -
YZOS03_RS06595 (YZOS03_11800) 1335097..1335807 + 711 WP_042524636.1 MalM family protein -
YZOS03_RS06600 1336380..1336469 + 90 WP_201773553.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1266431..1355952 89521
- inside Integron - - 1273249..1346674 73425


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T36784 WP_005377002.1 NZ_AP023185:c1331540-1331250 [Vibrio alginolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T36784 NZ_AP023185:c1331540-1331250 [Vibrio alginolyticus]
ATGACCTATAAACTCGACTTTAAAAAGAGTGCACTCAAAGAGTGGAAAAAGCTTGGCTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAGCTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTTGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT36784 WP_005377003.1 NZ_AP023185:c1331778-1331530 [Vibrio alginolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT36784 NZ_AP023185:c1331778-1331530 [Vibrio alginolyticus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTGCCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTGGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References