Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1329149..1329708 Replicon chromosome
Accession NZ_AP023185
Organism Vibrio alginolyticus strain YZOS-03

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag YZOS03_RS06520 Protein ID WP_005398411.1
Coordinates 1329149..1329427 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag YZOS03_RS06525 Protein ID WP_005398409.1
Coordinates 1329424..1329708 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YZOS03_RS06450 1324161..1324223 + 63 Protein_1189 DUF3265 domain-containing protein -
YZOS03_RS06460 (YZOS03_11630) 1324300..1324878 + 579 WP_017821397.1 ankyrin repeat domain-containing protein -
YZOS03_RS06465 1324860..1324985 + 126 WP_213987841.1 DUF3265 domain-containing protein -
YZOS03_RS06470 (YZOS03_11640) 1325025..1325570 + 546 WP_054579716.1 N-acetyltransferase -
YZOS03_RS06475 1325585..1325685 + 101 Protein_1193 DUF3265 domain-containing protein -
YZOS03_RS06480 (YZOS03_11650) 1325714..1326673 + 960 WP_213987840.1 restriction endonuclease -
YZOS03_RS06485 (YZOS03_11660) 1326802..1327182 + 381 WP_213987839.1 DUF4087 domain-containing protein -
YZOS03_RS06490 1327209..1327298 + 90 WP_109170471.1 DUF3265 domain-containing protein -
YZOS03_RS06495 (YZOS03_11670) 1327342..1327824 + 483 WP_017821432.1 hypothetical protein -
YZOS03_RS06500 (YZOS03_11680) 1327963..1328319 + 357 WP_017633715.1 cell envelope integrity protein TolA -
YZOS03_RS06505 1328346..1328438 + 93 WP_196363379.1 DUF3265 domain-containing protein -
YZOS03_RS06510 (YZOS03_11690) 1328471..1329013 + 543 WP_206949760.1 N-acetyltransferase -
YZOS03_RS06515 1329031..1329120 + 90 WP_073514058.1 DUF3265 domain-containing protein -
YZOS03_RS06520 (YZOS03_11700) 1329149..1329427 - 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
YZOS03_RS06525 (YZOS03_11710) 1329424..1329708 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
YZOS03_RS06530 (YZOS03_11720) 1329910..1330386 + 477 WP_024702472.1 GNAT family N-acetyltransferase -
YZOS03_RS06535 1330401..1330493 + 93 WP_080540751.1 DUF3265 domain-containing protein -
YZOS03_RS06540 (YZOS03_11730) 1330531..1331124 + 594 WP_213987838.1 hypothetical protein -
YZOS03_RS06545 1331142..1331231 + 90 WP_206949765.1 DUF3265 domain-containing protein -
YZOS03_RS06550 (YZOS03_11740) 1331250..1331540 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin -
YZOS03_RS06555 (YZOS03_11750) 1331530..1331778 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
YZOS03_RS06560 1331835..1331921 + 87 WP_225492314.1 DUF3265 domain-containing protein -
YZOS03_RS06565 (YZOS03_11760) 1331971..1332480 + 510 WP_206949758.1 AAA family ATPase -
YZOS03_RS06570 (YZOS03_11770) 1332615..1333376 + 762 WP_031852916.1 DUF4145 domain-containing protein -
YZOS03_RS06575 1333363..1333494 + 132 WP_248475487.1 DUF3265 domain-containing protein -
YZOS03_RS06580 (YZOS03_11780) 1333532..1334230 + 699 WP_191118274.1 hypothetical protein -
YZOS03_RS06585 1334253..1334345 + 93 WP_199479330.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1266431..1355952 89521
- inside Integron - - 1273249..1346674 73425


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T36783 WP_005398411.1 NZ_AP023185:c1329427-1329149 [Vibrio alginolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T36783 NZ_AP023185:c1329427-1329149 [Vibrio alginolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGAGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTCTCTTACTGGGTCGAGGGCGATATCATCAGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT36783 WP_005398409.1 NZ_AP023185:c1329708-1329424 [Vibrio alginolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT36783 NZ_AP023185:c1329708-1329424 [Vibrio alginolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCTGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References