Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 1291609..1292168 | Replicon | chromosome |
| Accession | NZ_AP023185 | ||
| Organism | Vibrio alginolyticus strain YZOS-03 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A2I3C6F2 |
| Locus tag | YZOS03_RS06135 | Protein ID | WP_005377065.1 |
| Coordinates | 1291609..1291887 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A2I3C6F3 |
| Locus tag | YZOS03_RS06140 | Protein ID | WP_005487956.1 |
| Coordinates | 1291884..1292168 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| YZOS03_RS06090 | 1286932..1287021 | + | 90 | WP_079740867.1 | DUF3265 domain-containing protein | - |
| YZOS03_RS06095 (YZOS03_11130) | 1287060..1287509 | + | 450 | WP_064368559.1 | hypothetical protein | - |
| YZOS03_RS06100 | 1288077..1288166 | + | 90 | WP_079858647.1 | DUF3265 domain-containing protein | - |
| YZOS03_RS06105 (YZOS03_11140) | 1288194..1288517 | + | 324 | WP_038217934.1 | hypothetical protein | - |
| YZOS03_RS06110 (YZOS03_11150) | 1288654..1289379 | + | 726 | WP_064368558.1 | hypothetical protein | - |
| YZOS03_RS06115 (YZOS03_11160) | 1289519..1289920 | + | 402 | WP_017636213.1 | HIT family protein | - |
| YZOS03_RS06120 | 1289954..1290046 | + | 93 | WP_197649978.1 | DUF3265 domain-containing protein | - |
| YZOS03_RS06125 (YZOS03_11170) | 1290086..1290511 | + | 426 | WP_025507144.1 | hypothetical protein | - |
| YZOS03_RS06130 | 1291451..1291580 | + | 130 | Protein_1125 | DUF3265 domain-containing protein | - |
| YZOS03_RS06135 (YZOS03_11180) | 1291609..1291887 | - | 279 | WP_005377065.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| YZOS03_RS06140 (YZOS03_11190) | 1291884..1292168 | - | 285 | WP_005487956.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| YZOS03_RS06145 (YZOS03_11200) | 1292367..1292939 | + | 573 | WP_064368557.1 | hypothetical protein | - |
| YZOS03_RS06150 (YZOS03_11210) | 1293055..1293513 | + | 459 | WP_064368556.1 | GNAT family N-acetyltransferase | - |
| YZOS03_RS06155 | 1293491..1293577 | + | 87 | Protein_1130 | DUF3265 domain-containing protein | - |
| YZOS03_RS06160 (YZOS03_11220) | 1293646..1294002 | - | 357 | WP_064368555.1 | hypothetical protein | - |
| YZOS03_RS06165 (YZOS03_11230) | 1294203..1294841 | + | 639 | WP_064368554.1 | hypothetical protein | - |
| YZOS03_RS06170 (YZOS03_11240) | 1294993..1295166 | + | 174 | WP_223829033.1 | SH3 domain-containing protein | - |
| YZOS03_RS06175 (YZOS03_11260) | 1295833..1296522 | + | 690 | WP_064368553.1 | hypothetical protein | - |
| YZOS03_RS06180 | 1296544..1296636 | + | 93 | WP_010644587.1 | DUF3265 domain-containing protein | - |
| YZOS03_RS06185 | 1297071..1297160 | + | 90 | WP_231972262.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1266431..1355952 | 89521 | |
| - | inside | Integron | - | - | 1273249..1346674 | 73425 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10905.60 Da Isoelectric Point: 4.3430
>T36782 WP_005377065.1 NZ_AP023185:c1291887-1291609 [Vibrio alginolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIISYWVEGDIIRVM
RVLHQKQKFPTD
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIISYWVEGDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T36782 NZ_AP023185:c1291887-1291609 [Vibrio alginolyticus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGCGTACAACGAGATGGTA
TCCGCGGACGATTACTCATTATTCCTGAGATTTCGATGATTATCTCTTACTGGGTCGAGGGAGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTCAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGCGTACAACGAGATGGTA
TCCGCGGACGATTACTCATTATTCCTGAGATTTCGATGATTATCTCTTACTGGGTCGAGGGAGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11082.40 Da Isoelectric Point: 9.2167
>AT36782 WP_005487956.1 NZ_AP023185:c1292168-1291884 [Vibrio alginolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQNAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQNAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT36782 NZ_AP023185:c1292168-1291884 [Vibrio alginolyticus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAGCAACTTGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAGTCCGTTTTCGTTGAGCACCAAAATGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGCCGTGAACTTACTGAGCAACTTGCTGAACAACAAAGAAAAACATTGTCTCACGATGCATGGCTAA
CTGAACAAGTAAATCTAGCATTTGAGAAGTTTGACTCAGGAAAGTCCGTTTTCGTTGAGCACCAAAATGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I3C6F2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I3C6F3 |