Detailed information of TA system TA036780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3318460..3319115
• Replicon: chromosome
• Accession: NZ_AP023184
• Organism: Buttiauxella agrestis strain DSM 9389

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BADSM9389_RS15460
• Protein ID: WP_172895304.1
• Coordinates: 3318460..3318852 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A085GHF1
• Locus tag: BADSM9389_RS15465
• Protein ID: WP_034493852.1
• Coordinates: 3318852..3319115 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BADSM9389_RS15430	3313535..3314320	+	786	WP_172895299.1	transcriptional regulator LldR	-
BADSM9389_RS15435	3314317..3315498	+	1182	WP_172895300.1	FMN-dependent L-lactate dehydrogenase LldD	-
BADSM9389_RS15440	3316025..3316453	-	429	WP_172895301.1	OsmC family protein	-
BADSM9389_RS15445	3316612..3317145	+	534	WP_172895302.1	tetratricopeptide repeat protein	-
BADSM9389_RS15450	3317155..3317682	+	528	WP_197969166.1	RNA polymerase sigma factor	-
BADSM9389_RS15455	3317679..3318428	+	750	WP_172895303.1	anti-sigma factor	-
BADSM9389_RS15460	3318460..3318852	-	393	WP_172895304.1	type II toxin-antitoxin system VapC family toxin	Toxin
BADSM9389_RS15465	3318852..3319115	-	264	WP_034493852.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
BADSM9389_RS15470	3319386..3319667	-	282	WP_034493851.1	acetolactate synthase small subunit	-
BADSM9389_RS15475	3319671..3321359	-	1689	WP_172895305.1	acetolactate synthase large subunit	-
BADSM9389_RS15480	3321470..3321631	-	162	WP_172895306.1	ilvB operon leader peptide IvbL	-
BADSM9389_RS15485	3321687..3322709	-	1023	WP_172895307.1	GTP-binding protein	-
BADSM9389_RS15490	3322725..3322922	-	198	WP_172895308.1	YbdD/YjiX family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14301.59 Da
• Isoelectric Point: 9.5113

>T36780 WP_172895304.1 NZ_AP023184:c3318852-3318460 [Buttiauxella agrestis]
MVWMLDTNTVSYFLRRHPQVMAKISNIPPSSIVISSITEAELLFGVAKRQNKTLKAAVMGFLDTVSVYPWDSAAAETYGK
LRASLEKKGQVMGTLDMLIAAHALSEKTTIVTSDRAFHSVAGLRAEDWTV

Nucleotide

• Length: 393 bp

>T36780 NZ_AP023184:c3318852-3318460 [Buttiauxella agrestis]
ATGGTCTGGATGCTGGATACCAATACGGTCAGTTATTTTTTACGCCGACATCCACAGGTCATGGCGAAGATTTCAAACAT
TCCGCCTTCCAGTATTGTGATTTCAAGTATTACGGAGGCGGAGCTGCTTTTTGGCGTGGCAAAACGGCAAAATAAAACCC
TGAAGGCAGCAGTTATGGGCTTTCTTGATACTGTATCGGTGTACCCATGGGACAGCGCAGCGGCAGAAACGTACGGTAAA
CTCAGGGCGAGTCTGGAGAAAAAAGGCCAGGTGATGGGCACGTTAGACATGTTGATTGCGGCTCACGCATTAAGTGAAAA
AACCACTATTGTGACCAGCGACCGCGCATTCCATAGTGTGGCAGGGCTACGCGCGGAAGACTGGACTGTCTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10065.41 Da
• Isoelectric Point: 8.5948

>AT36780 WP_034493852.1 NZ_AP023184:c3319115-3318852 [Buttiauxella agrestis]
MERIAKIFKNGRNQAVRLPVEFEFDTDRVYIRQDKEGNVILSKRPAKPDNWDNVISLIAKARVPDNFLDAEERNQPPADR
DPFAGIK

Nucleotide

• Length: 264 bp

>AT36780 NZ_AP023184:c3319115-3318852 [Buttiauxella agrestis]
ATGGAACGTATCGCGAAGATTTTTAAAAATGGCAGGAACCAGGCGGTGAGGTTACCGGTGGAATTCGAATTCGATACCGA
CAGGGTTTATATCCGACAAGACAAGGAAGGCAATGTGATTCTTTCAAAAAGACCAGCAAAACCAGATAACTGGGATAACG
TTATCTCTCTGATTGCAAAAGCGCGTGTGCCAGATAACTTCCTGGATGCAGAAGAACGCAATCAGCCTCCTGCGGACAGA
GATCCTTTTGCAGGAATTAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A085GHF1