Detailed information of TA system TA036768

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 799663..800332
• Replicon: chromosome
• Accession: NZ_AP023184
• Organism: Buttiauxella agrestis strain DSM 9389

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: BADSM9389_RS03795
• Protein ID: WP_172893285.1
• Coordinates: 799910..800332 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A085G3P4
• Locus tag: BADSM9389_RS03790
• Protein ID: WP_034498232.1
• Coordinates: 799663..799929 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BADSM9389_RS03770	795170..796603	-	1434	WP_172893283.1	6-phospho-beta-glucosidase	-
BADSM9389_RS03775	796769..797497	-	729	WP_034498249.1	MurR/RpiR family transcriptional regulator	-
BADSM9389_RS03780	797736..798389	+	654	WP_034498239.1	hemolysin III family protein	-
BADSM9389_RS03785	798430..799416	-	987	WP_172893284.1	tRNA-modifying protein YgfZ	-
BADSM9389_RS03790	799663..799929	+	267	WP_034498232.1	FAD assembly factor SdhE	Antitoxin
BADSM9389_RS03795	799910..800332	+	423	WP_172893285.1	protein YgfX	Toxin
BADSM9389_RS03800	800340..800861	-	522	WP_172893286.1	flavodoxin FldB	-
BADSM9389_RS03805	800975..801871	+	897	WP_172893287.1	site-specific tyrosine recombinase XerD	-
BADSM9389_RS03810	801896..802612	+	717	WP_172893288.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
BADSM9389_RS03815	802620..804353	+	1734	WP_172893289.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16603.47 Da
• Isoelectric Point: 10.4064

>T36768 WP_172893285.1 NZ_AP023184:799910-800332 [Buttiauxella agrestis]
VVLWQSDLRVSWRAQWLSLLAHGLVALFVLLMPWPMSYTLIWMLLLSLVVFDSVRSQRRIHACQGEMKILTDYHLRWQNQ
EWEIVGSPWMLRSGMMLRIRRDGRKRCQHLWLSADSMDTGEWRDLRHLMLQQQASGSGQA

Nucleotide

• Length: 423 bp

>T36768 NZ_AP023184:799910-800332 [Buttiauxella agrestis]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCCTGGCGTGCACAATGGCTTTCACTATTGGCCCACGGTTTGGTCGCACT
GTTCGTGCTTCTTATGCCGTGGCCGATGAGCTACACGCTAATCTGGATGCTACTGCTTTCGCTGGTGGTATTTGACAGCG
TACGCAGCCAACGCCGTATACATGCCTGCCAGGGCGAAATGAAAATCCTGACCGACTACCACCTGCGTTGGCAAAATCAG
GAATGGGAAATCGTCGGCTCGCCCTGGATGCTGCGTAGCGGCATGATGTTGCGCATACGCCGCGATGGTCGTAAACGCTG
TCAGCATCTATGGTTGTCTGCCGACAGCATGGATACTGGCGAATGGCGTGATTTACGCCACCTTATGCTGCAACAGCAAG
CCAGCGGCAGTGGTCAAGCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10441.94 Da
• Isoelectric Point: 5.1238

>AT36768 WP_034498232.1 NZ_AP023184:799663-799929 [Buttiauxella agrestis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSAEDKQLFVRLLESDDPDLFNWLMNHGKPADTELQRMVTLIQTRN
KERGPVAI

Nucleotide

• Length: 267 bp

>AT36768 NZ_AP023184:799663-799929 [Buttiauxella agrestis]
ATGGATATCAATAACAAAGCCCGAATTCATTGGGCGTGCCGCCGGGGAATGCGCGAGCTGGATATTTCGATTATGCCATT
CTTTGAATATGAATATGACTCGTTAAGCGCTGAGGATAAACAATTGTTTGTTCGCTTGCTGGAAAGCGATGATCCAGACC
TGTTCAATTGGTTAATGAATCATGGCAAACCGGCAGATACAGAGCTGCAACGGATGGTGACACTGATTCAGACGCGGAAT
AAAGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A085G3P4