Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 791968..792629 Replicon plasmid PPGU19_p3
Accession NZ_AP023183
Organism Paraburkholderia sp. PGU19

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H1204_RS50750 Protein ID WP_180736645.1
Coordinates 792198..792629 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H1204_RS50745 Protein ID WP_091788763.1
Coordinates 791968..792198 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1204_RS50725 787452..788657 + 1206 WP_180737008.1 AAA family ATPase -
H1204_RS50730 788654..789643 + 990 WP_180736643.1 ParB/RepB/Spo0J family partition protein -
H1204_RS50735 790803..790982 + 180 WP_180737009.1 type II toxin-antitoxin system ParD family antitoxin -
H1204_RS50740 791456..791593 + 138 WP_180736644.1 hypothetical protein -
H1204_RS50745 791968..792198 + 231 WP_091788763.1 CopG family transcriptional regulator Antitoxin
H1204_RS50750 792198..792629 + 432 WP_180736645.1 PIN domain-containing protein Toxin
H1204_RS50755 793041..793283 + 243 WP_180737010.1 type II toxin-antitoxin system ParD family antitoxin -
H1204_RS50760 793280..793579 + 300 WP_180736646.1 type II toxin-antitoxin system RelE/ParE family toxin -
H1204_RS50765 793910..794662 + 753 WP_180736647.1 hypothetical protein -
H1204_RS50770 794647..795339 + 693 WP_180736648.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB / htpB 1..852821 852821


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15568.67 Da        Isoelectric Point: 5.9926

>T36764 WP_180736645.1 NZ_AP023183:792198-792629 [Paraburkholderia sp. PGU19]
MTYLLDVNVLIALLDAGHVQHEAAHEWFGRAGHAAWATCPLTENGVLRIIGNPRYPNTLETPAAVAPLVAQLRAHPGHTF
WSDDLSMLDPEHVDLSRVLATDQVTDTYLLALARRHGGALATFDRRLVADAVPDGARHLEVIG

Download         Length: 432 bp

>T36764 NZ_AP023183:792198-792629 [Paraburkholderia sp. PGU19]
ATGACGTATCTGCTTGACGTCAACGTACTGATTGCGCTGCTCGACGCGGGCCACGTACAGCACGAGGCCGCGCACGAATG
GTTCGGCCGGGCAGGGCACGCCGCTTGGGCGACCTGCCCGCTGACAGAAAACGGCGTGCTGCGCATCATCGGCAATCCGC
GCTACCCGAACACGCTGGAGACGCCGGCCGCGGTCGCGCCGCTCGTCGCGCAGCTTCGAGCACATCCTGGCCACACCTTC
TGGTCTGACGACCTGAGCATGCTCGATCCGGAGCACGTTGACCTGAGCCGCGTCCTCGCGACCGACCAGGTGACCGACAC
GTACCTGCTCGCCCTCGCGCGCCGCCATGGAGGGGCGCTGGCCACCTTCGACCGCCGGCTGGTCGCCGATGCGGTGCCCG
ACGGTGCGCGCCACCTCGAAGTCATTGGTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8262.45 Da        Isoelectric Point: 11.5000

>AT36764 WP_091788763.1 NZ_AP023183:791968-792198 [Paraburkholderia sp. PGU19]
MRTTLDIDDDVLALARARADREHVSIGRIISQLARAALQRPAVAPATRNGLPVLPNARTARTVTPEVVNQLRDEAP

Download         Length: 231 bp

>AT36764 NZ_AP023183:791968-792198 [Paraburkholderia sp. PGU19]
ATGCGAACCACCCTCGATATCGACGACGACGTACTCGCCCTCGCACGCGCGCGTGCCGACCGCGAGCACGTGTCGATCGG
CCGCATCATCTCGCAACTCGCGCGCGCAGCGCTGCAGCGTCCCGCAGTCGCTCCGGCCACGCGCAACGGCTTGCCGGTGC
TGCCGAACGCGCGCACCGCGCGCACGGTCACGCCCGAAGTCGTCAACCAGCTGCGCGACGAGGCGCCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References