Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2000023..2001773 Replicon chromosome
Accession NZ_AP023180
Organism Paraburkholderia sp. PGU19

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag H1204_RS26575 Protein ID WP_180731486.1
Coordinates 2000880..2001773 (-) Length 298 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag H1204_RS26570 Protein ID WP_180731485.1
Coordinates 2000023..2000883 (-) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H1204_RS26550 1995222..1996718 - 1497 WP_180731481.1 aldehyde dehydrogenase -
H1204_RS26555 1996743..1997573 - 831 WP_180731482.1 aspartate dehydrogenase -
H1204_RS26560 1997566..1999224 - 1659 WP_180731483.1 thiamine pyrophosphate-binding protein -
H1204_RS26565 1999217..2000023 - 807 WP_180731484.1 SDR family oxidoreductase -
H1204_RS26570 2000023..2000883 - 861 WP_180731485.1 IclR family transcriptional regulator Antitoxin
H1204_RS26575 2000880..2001773 - 894 WP_180731486.1 alpha/beta fold hydrolase Toxin
H1204_RS26580 2001805..2002344 - 540 WP_180731487.1 cupin domain-containing protein -
H1204_RS26585 2002380..2003138 - 759 WP_180731488.1 SDR family oxidoreductase -
H1204_RS26590 2003131..2004219 - 1089 WP_091781013.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
H1204_RS26595 2004262..2004573 - 312 WP_042304475.1 hypothetical protein -
H1204_RS26600 2004575..2004892 - 318 WP_007587796.1 non-heme iron oxygenase ferredoxin subunit -
H1204_RS26605 2005334..2006407 + 1074 WP_180731489.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(50-276)

Antitoxin

Transcription regulator IclR, C-terminal

(144-267)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 31339.38 Da        Isoelectric Point: 7.4413

>T36762 WP_180731486.1 NZ_AP023180:c2001773-2000880 [Paraburkholderia sp. PGU19]
MSAALPVIADRNATLETRLSHFPAQRIAIASQRAIGYRAAGAAHADALPLVLLHGIGSGAASWVQQFESLGTTRRVFAWD
APGYGESTPVASASPTANEYSSALEQWLNVLKIERCVLIGHSLGAIIAGSFAASHAERVAGLLLISPAAGYGAASEEVRA
SKRDSRLAMLAELGPQGLADQRSANMLSPYADDASRNWVRWNMSRIVSTGYAQATHLLANADLASDVAKINGRIAVAVGA
EDTITPPSSCERIAQAARTRLQIIPRAGHAGYIEAGNEYTALIDAFCRVSDGYWSKA

Download         Length: 894 bp

>T36762 NZ_AP023180:c2001773-2000880 [Paraburkholderia sp. PGU19]
ATGTCCGCAGCCTTGCCCGTCATTGCCGATCGAAACGCCACGCTGGAAACGCGCCTCTCGCACTTCCCGGCGCAGCGGAT
CGCGATTGCGTCGCAACGCGCGATCGGTTATCGCGCAGCGGGTGCCGCACACGCTGATGCGTTGCCGCTCGTACTGTTGC
ACGGCATCGGCTCGGGCGCGGCTTCGTGGGTGCAACAGTTCGAATCGCTCGGCACGACGCGCCGCGTGTTCGCGTGGGAC
GCGCCGGGCTACGGCGAATCGACACCCGTTGCGTCGGCTTCGCCTACCGCGAACGAATACTCGAGCGCGCTCGAGCAATG
GCTCAATGTGCTCAAGATAGAACGTTGCGTACTGATCGGGCATTCGCTCGGCGCGATCATCGCGGGCTCGTTCGCAGCGT
CGCATGCGGAACGTGTCGCGGGGCTGCTGCTGATTTCGCCCGCAGCGGGCTACGGCGCGGCATCCGAAGAAGTGCGCGCG
TCGAAGCGCGACAGCCGCCTCGCGATGCTTGCCGAACTCGGCCCGCAAGGACTCGCGGACCAACGCAGCGCCAACATGCT
GTCGCCGTATGCCGACGACGCATCGCGTAACTGGGTGCGCTGGAACATGTCGCGCATCGTGTCGACCGGTTACGCGCAGG
CGACGCATCTGCTCGCCAACGCCGACCTCGCCAGCGATGTCGCGAAGATCAACGGCCGTATCGCCGTCGCGGTCGGCGCG
GAAGACACGATCACACCGCCGTCGTCATGCGAGCGGATCGCGCAGGCGGCGCGCACGCGCCTGCAGATCATCCCGCGCGC
GGGTCACGCGGGCTATATCGAAGCGGGCAATGAATACACCGCGCTCATCGACGCCTTCTGCCGCGTGAGCGACGGTTACT
GGAGTAAAGCATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31508.95 Da        Isoelectric Point: 6.5092

>AT36762 WP_180731485.1 NZ_AP023180:c2000883-2000023 [Paraburkholderia sp. PGU19]
MTPELTGTAPEAEDDRNDANYRVPGLERGLRILTEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADRDRN
YRLGVAVLRLGFEYLSSLELTDLGLPLIEGLRDATGLTTHIVIRDGRDVVFVAKAQSHAPVFSSVKVNVGTRLPAHATTH
GHVLMGDLTLDELRALYPEKTLERFTKHTPATVDELYERVKDDALRGFAISESSFENGISVISAPVRNDTGRIAAVITTT
IPRPQIDAALLDGGLIDKVRSAAEQLSLRLNYRPSAESRYMKALGL

Download         Length: 861 bp

>AT36762 NZ_AP023180:c2000883-2000023 [Paraburkholderia sp. PGU19]
ATGACCCCCGAATTGACGGGCACTGCGCCTGAAGCAGAAGACGACCGCAACGACGCGAATTACCGCGTGCCCGGACTCGA
ACGCGGCCTGCGCATTCTCACGGAATTTTCGCCGCGCGAGCCGGTGCTCGGCGCGCCCGAGTTGTCGAAGCGCCTCGGCA
TTCCGCGCACGACGGTTTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTGGAGCGCGCGGATCGCGACCGCAAC
TATCGCCTGGGCGTCGCGGTGCTGCGCCTCGGCTTCGAATATCTCAGCTCGCTTGAACTCACCGATCTCGGCTTGCCGTT
GATCGAAGGATTGCGCGACGCGACGGGACTGACCACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGA
AGGCGCAGAGTCACGCGCCCGTGTTCAGCTCGGTGAAGGTGAACGTCGGCACGCGGTTGCCCGCGCATGCGACCACGCAT
GGCCATGTCCTGATGGGCGATCTCACGCTCGACGAACTGCGCGCGCTGTATCCGGAGAAGACGCTTGAACGCTTCACGAA
ACACACGCCCGCCACCGTCGACGAACTGTACGAGCGCGTGAAGGACGACGCATTGCGCGGCTTCGCGATCAGCGAATCGT
CCTTTGAAAACGGCATTTCCGTCATCAGCGCGCCCGTGCGCAACGACACGGGCCGTATCGCCGCTGTGATCACGACGACG
ATTCCGCGTCCGCAGATCGACGCGGCGCTGCTGGACGGCGGCCTGATCGACAAGGTGCGCAGCGCGGCGGAGCAACTGTC
GCTGCGGCTGAACTATCGGCCGTCGGCGGAAAGCAGATACATGAAGGCATTGGGGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References