Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 177125..177708 Replicon plasmid PPGU16_p2
Accession NZ_AP023177
Organism Paraburkholderia sp. PGU16

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PPGU16_RS40055 Protein ID WP_180727617.1
Coordinates 177125..177505 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PPGU16_RS40060 Protein ID WP_180727618.1
Coordinates 177502..177708 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPGU16_RS40035 172350..173744 - 1395 WP_180727613.1 sigma-54 dependent transcriptional regulator -
PPGU16_RS40040 173895..174545 - 651 WP_180727614.1 glycosyltransferase family 2 protein -
PPGU16_RS40045 174647..175525 - 879 WP_180727615.1 manganese catalase family protein -
PPGU16_RS40050 175969..176346 + 378 WP_180727616.1 hypothetical protein -
PPGU16_RS40055 177125..177505 - 381 WP_180727617.1 PIN domain-containing protein Toxin
PPGU16_RS40060 177502..177708 - 207 WP_180727618.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PPGU16_RS40065 178003..178476 - 474 WP_180727619.1 RES domain-containing protein -
PPGU16_RS40070 178473..178901 - 429 WP_180727620.1 DUF2384 domain-containing protein -
PPGU16_RS40075 180245..180754 + 510 WP_180727621.1 hypothetical protein -
PPGU16_RS40080 180757..181041 - 285 WP_180727622.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..606703 606703


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-115)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13973.15 Da        Isoelectric Point: 6.3691

>T36761 WP_180727617.1 NZ_AP023177:c177505-177125 [Paraburkholderia sp. PGU16]
MSVLIDTSVWVDHFRRVNSRLVQLVTNDEAVTHPVVLVELACGTPPAPRARTLHDIGLLQHAKHPTWAEVMELIDARQLY
GRGCGSSDLTLLASTLMTPGALLWTLDKRLSQLAGELEVAYMHDIH

Download         Length: 381 bp

>T36761 NZ_AP023177:c177505-177125 [Paraburkholderia sp. PGU16]
ATGAGCGTCCTCATCGATACATCGGTGTGGGTTGATCATTTCCGTCGGGTCAATTCGAGACTTGTTCAATTGGTCACAAA
CGACGAGGCCGTTACTCATCCAGTCGTGCTTGTTGAACTCGCCTGTGGCACACCGCCCGCTCCCCGGGCGCGGACACTTC
ACGACATCGGGCTGCTGCAACATGCGAAGCACCCGACATGGGCCGAGGTCATGGAGTTGATCGATGCCAGACAGCTTTAC
GGTCGAGGCTGCGGTAGCAGCGACTTGACGCTGCTGGCGTCGACATTAATGACTCCCGGGGCGTTACTCTGGACATTAGA
CAAGAGACTAAGCCAGCTCGCTGGTGAACTTGAAGTCGCGTATATGCATGACATTCACTAA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7662.76 Da        Isoelectric Point: 4.9987

>AT36761 WP_180727618.1 NZ_AP023177:c177708-177502 [Paraburkholderia sp. PGU16]
MRTTVTIDDNLYERALELADPEMDKADLFRVAMQTFVRVQAGKRLAALGGTVPDMPDIPRRRSEPSTQ

Download         Length: 207 bp

>AT36761 NZ_AP023177:c177708-177502 [Paraburkholderia sp. PGU16]
ATGCGGACCACGGTTACGATCGATGATAACCTTTACGAGCGTGCGCTCGAGCTTGCTGATCCAGAGATGGATAAAGCCGA
TCTGTTTCGGGTCGCGATGCAGACATTCGTTCGGGTTCAGGCGGGAAAGCGTCTGGCAGCCCTCGGAGGCACCGTGCCCG
ATATGCCCGACATCCCGCGGCGCCGCTCTGAGCCTTCTACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References