Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1893754..1895504 Replicon chromosome
Accession NZ_AP023175
Organism Paraburkholderia sp. PGU16

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PPGU16_RS25195 Protein ID WP_180723120.1
Coordinates 1893754..1894647 (+) Length 298 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag PPGU16_RS25200 Protein ID WP_180723121.1
Coordinates 1894644..1895504 (+) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPGU16_RS25165 1889117..1890190 - 1074 WP_180723115.1 porin -
PPGU16_RS25170 1890631..1890948 + 318 WP_091781007.1 non-heme iron oxygenase ferredoxin subunit -
PPGU16_RS25175 1890950..1891261 + 312 WP_180723116.1 hypothetical protein -
PPGU16_RS25180 1891305..1892393 + 1089 WP_180723117.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
PPGU16_RS25185 1892386..1893153 + 768 WP_180723118.1 SDR family oxidoreductase -
PPGU16_RS25190 1893189..1893728 + 540 WP_180723119.1 cupin domain-containing protein -
PPGU16_RS25195 1893754..1894647 + 894 WP_180723120.1 alpha/beta fold hydrolase Toxin
PPGU16_RS25200 1894644..1895504 + 861 WP_180723121.1 IclR family transcriptional regulator Antitoxin
PPGU16_RS25205 1895504..1896310 + 807 WP_180723122.1 SDR family oxidoreductase -
PPGU16_RS25210 1896303..1897961 + 1659 WP_180723123.1 thiamine pyrophosphate-binding protein -
PPGU16_RS25215 1897954..1898784 + 831 WP_180723124.1 aspartate dehydrogenase -
PPGU16_RS25220 1898812..1900308 + 1497 WP_180723125.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(50-275)

Antitoxin

Transcription regulator IclR, C-terminal

(144-267)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 31225.21 Da        Isoelectric Point: 6.0198

>T36760 WP_180723120.1 NZ_AP023175:1893754-1894647 [Paraburkholderia sp. PGU16]
MSAALPVTVDRTVTLETRLSHFPARRIEIAPQCAIGYREAGAAHADALPLVLLHGIGSGAASWVQQLEALGTTRRVFAWD
APGYGESTPVASASPAASEYASAVEQWLNVLNIERCVLVGHSLGAIIAGSFAASHAERVAGLLLISPAAGYGAASEEVRA
SKRDSRLAMLAELGPQGLADQRSANMLSPHADDASRDWVRWNMSRIVPHGYAQATHLLANADLASDVTTYTGRITVAVGA
EDVITPPSSCERIALAANTRLQIIPRAGHAGYIEASTDYTALIDAFCCASDGQWSKA

Download         Length: 894 bp

>T36760 NZ_AP023175:1893754-1894647 [Paraburkholderia sp. PGU16]
ATGTCCGCAGCCTTGCCCGTCACTGTCGATCGAACCGTCACGCTGGAAACGCGCCTCTCGCACTTCCCGGCACGGCGGAT
CGAGATTGCGCCGCAATGCGCGATCGGCTATCGCGAAGCGGGTGCCGCACATGCCGATGCGCTGCCGCTCGTGCTGTTGC
ACGGTATCGGCTCGGGCGCGGCTTCGTGGGTGCAACAACTCGAAGCGTTGGGCACGACGCGCCGCGTGTTCGCGTGGGAC
GCGCCGGGCTATGGCGAATCGACGCCTGTTGCATCGGCTTCGCCCGCCGCGAGCGAGTACGCGAGTGCAGTCGAGCAATG
GCTCAACGTACTAAACATAGAACGTTGCGTGCTGGTCGGTCATTCGCTTGGCGCGATCATCGCGGGCTCGTTCGCGGCAT
CGCACGCTGAGCGCGTCGCCGGTCTGTTGCTGATTTCGCCCGCGGCGGGCTACGGCGCGGCATCCGAAGAAGTGCGCGCG
TCGAAGCGCGACAGCCGCCTTGCGATGCTCGCCGAACTCGGCCCGCAAGGACTCGCGGACCAACGCAGCGCCAACATGTT
GTCGCCGCACGCCGATGACGCATCGCGCGACTGGGTCCGCTGGAACATGTCGCGCATCGTGCCGCACGGTTACGCACAGG
CGACGCATCTGCTCGCCAACGCCGACCTCGCCAGCGATGTCACGACGTACACAGGCCGTATCACCGTCGCGGTCGGTGCA
GAAGACGTGATTACGCCACCGTCGTCGTGTGAACGGATCGCGCTCGCAGCAAACACGCGTTTGCAGATCATCCCGCGCGC
GGGTCACGCGGGCTATATCGAGGCGAGCACTGACTACACCGCGCTCATCGACGCATTCTGCTGCGCGAGCGACGGCCAAT
GGAGCAAGGCATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31509.93 Da        Isoelectric Point: 6.2548

>AT36760 WP_180723121.1 NZ_AP023175:1894644-1895504 [Paraburkholderia sp. PGU16]
MTPELTGTAPEAEEDRNDASYRVPGLERGLRILTEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADRDRN
YRLGVAVLRLGFEYLSSLELTDLGLPLIEGLRDATGLTTHIVIRDGRDVVFVAKAQSHAPVFSSVKVNVGTRLPAHATTH
GHVLMGDLSLDELRALYPEQTLERFTKHTPATVDELYERVKDDAVRGFAISESSFENGISVISVPVRNDTGRIAAVITTT
IPRPQIDAALLDGGLIDKVRTAAEQLSLRLNYRPSAESRYMKALGL

Download         Length: 861 bp

>AT36760 NZ_AP023175:1894644-1895504 [Paraburkholderia sp. PGU16]
ATGACCCCCGAATTGACGGGCACTGCACCTGAAGCAGAAGAAGACCGCAACGACGCGAGCTATCGCGTGCCCGGACTCGA
ACGCGGCCTGCGCATTCTCACGGAGTTTTCGCCGCGCGAACCGGTGCTCGGCGCGCCCGAGTTGTCGAAGCGCCTCGGCA
TTCCGCGCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTAGGCTTCCTGGAGCGGGCAGATCGCGATCGTAAC
TATCGCCTGGGCGTCGCGGTGCTGCGCCTCGGCTTCGAATATCTCAGTTCGCTCGAACTCACCGATCTCGGCTTGCCGCT
GATCGAAGGGTTGCGCGACGCGACGGGCCTGACCACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGA
AGGCGCAGAGTCACGCGCCCGTGTTCAGCTCGGTGAAGGTAAACGTCGGCACGCGGCTGCCCGCGCATGCAACGACGCAT
GGCCACGTGCTGATGGGCGATCTGTCGCTCGACGAACTGCGTGCGCTGTATCCGGAGCAGACGCTTGAACGTTTCACCAA
ACACACGCCCGCCACTGTCGATGAACTGTACGAGCGCGTGAAGGACGACGCAGTGCGCGGTTTCGCGATCAGCGAATCGT
CGTTTGAAAACGGCATTTCCGTGATCAGTGTGCCTGTGCGCAACGATACGGGCCGCATCGCCGCCGTCATCACGACGACG
ATCCCGCGTCCGCAGATCGACGCGGCGCTGCTCGATGGCGGCCTCATCGACAAGGTGCGCACTGCGGCGGAGCAACTGTC
GCTGCGGCTGAACTATCGGCCGTCGGCGGAAAGCAGGTACATGAAGGCATTGGGGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References