Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1725214..1725839 Replicon chromosome
Accession NZ_AP023175
Organism Paraburkholderia sp. PGU16

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PPGU16_RS24345 Protein ID WP_180722968.1
Coordinates 1725214..1725558 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PPGU16_RS24350 Protein ID WP_180722969.1
Coordinates 1725567..1725839 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPGU16_RS24315 1720405..1720764 + 360 WP_180722962.1 nuclear transport factor 2 family protein -
PPGU16_RS24320 1720855..1721700 + 846 WP_180722963.1 AraC family transcriptional regulator -
PPGU16_RS24325 1721709..1722293 - 585 WP_180722964.1 flavin reductase family protein -
PPGU16_RS24330 1722460..1722786 - 327 WP_180722965.1 hypothetical protein -
PPGU16_RS24335 1723035..1724249 - 1215 WP_180722966.1 DUF2252 domain-containing protein -
PPGU16_RS24340 1724472..1725191 + 720 WP_180722967.1 GNAT family N-acetyltransferase -
PPGU16_RS24345 1725214..1725558 - 345 WP_180722968.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PPGU16_RS24350 1725567..1725839 - 273 WP_180722969.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PPGU16_RS24355 1726097..1726621 - 525 WP_180722970.1 GNAT family N-acetyltransferase -
PPGU16_RS24360 1726729..1727205 - 477 WP_180722971.1 VOC family protein -
PPGU16_RS24365 1727299..1727787 - 489 WP_180722972.1 VOC family protein -
PPGU16_RS24370 1727937..1728170 - 234 WP_180722973.1 YXWGXW repeat-containing protein -
PPGU16_RS24375 1728225..1729385 - 1161 WP_180722974.1 DUF1501 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-111)

Antitoxin

Antitoxin PemI-like

(5-81)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12847.95 Da        Isoelectric Point: 7.8881

>T36759 WP_180722968.1 NZ_AP023175:c1725558-1725214 [Paraburkholderia sp. PGU16]
MKNGVPEIGDVWWMRLEPVVGHEQGGSYPRPVVVLSHYEHNGPAQRIVAVPCTSKIRGFSTEIPVSALPKPCVALIDQIT
TLDWVARRGEFREERIAQPELDAIRRSLKAFLMM

Download         Length: 345 bp

>T36759 NZ_AP023175:c1725558-1725214 [Paraburkholderia sp. PGU16]
ATGAAGAACGGTGTTCCCGAAATCGGCGATGTGTGGTGGATGAGGCTCGAGCCCGTGGTCGGGCACGAGCAGGGCGGCAG
TTATCCTCGGCCTGTGGTGGTGCTATCGCATTACGAGCACAACGGTCCGGCACAGCGCATTGTCGCCGTGCCGTGTACGT
CGAAGATTCGCGGCTTTTCGACGGAGATTCCTGTCTCCGCTTTGCCAAAACCGTGCGTCGCGCTGATCGACCAGATCACC
ACGCTCGACTGGGTGGCGCGGCGCGGTGAATTCAGGGAAGAGCGGATCGCGCAGCCCGAACTGGATGCGATCCGCCGCAG
TTTGAAAGCATTCCTGATGATGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9951.01 Da        Isoelectric Point: 4.1492

>AT36759 WP_180722969.1 NZ_AP023175:c1725839-1725567 [Paraburkholderia sp. PGU16]
MAIQTIKRWGNSLAVRIPASLADELHLREDQEVDMVVADGALVATPTIRTFNWDEYREQLAARPGDVHPTIDHGAAVGSE
LADPTDQDDW

Download         Length: 273 bp

>AT36759 NZ_AP023175:c1725839-1725567 [Paraburkholderia sp. PGU16]
ATGGCTATTCAGACAATCAAGCGGTGGGGCAACAGCCTTGCAGTGCGCATTCCCGCAAGCCTGGCTGACGAACTGCACCT
GCGCGAAGATCAGGAAGTCGACATGGTGGTAGCGGACGGAGCGCTCGTCGCCACGCCCACCATCAGGACGTTCAATTGGG
ACGAGTATCGCGAGCAGCTCGCGGCGCGGCCCGGCGACGTGCATCCGACCATCGATCATGGCGCGGCGGTAGGTTCGGAA
CTTGCCGATCCAACGGACCAGGACGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References