Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2647465..2648061 Replicon chromosome
Accession NZ_AP023174
Organism Paraburkholderia sp. PGU16

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag PPGU16_RS11795 Protein ID WP_180720144.1
Coordinates 2647762..2648061 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PPGU16_RS11790 Protein ID WP_180720143.1
Coordinates 2647465..2647758 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPGU16_RS11760 2642728..2644278 - 1551 WP_180720138.1 sodium:solute symporter -
PPGU16_RS11765 2644275..2644502 - 228 WP_036003627.1 DUF3311 domain-containing protein -
PPGU16_RS11770 2644863..2645780 - 918 WP_180720139.1 spermidine synthase -
PPGU16_RS11775 2645777..2646250 - 474 WP_180720140.1 DNA-deoxyinosine glycosylase -
PPGU16_RS11780 2646250..2646927 - 678 WP_180720141.1 chorismate lyase -
PPGU16_RS11785 2647124..2647390 + 267 WP_180720142.1 hypothetical protein -
PPGU16_RS11790 2647465..2647758 - 294 WP_180720143.1 putative addiction module antidote protein Antitoxin
PPGU16_RS11795 2647762..2648061 - 300 WP_180720144.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PPGU16_RS11800 2648220..2650112 - 1893 WP_180720145.1 molecular chaperone HtpG -
PPGU16_RS11805 2650249..2651709 - 1461 WP_180720146.1 PLP-dependent aminotransferase family protein -
PPGU16_RS11810 2652103..2652783 + 681 WP_180720147.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Uncharacterized protein HI1420

(3-96)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11135.68 Da        Isoelectric Point: 8.9448

>T36758 WP_180720144.1 NZ_AP023174:c2648061-2647762 [Paraburkholderia sp. PGU16]
MPSIRTTDVFDHWFVRIRDLRARVRVQARIDRLAMGNPGDHKSVGAGVTELRIDYGPGYRVYYTQRGSILVVLLCGGDKS
SQRDDIAQAKDLAANLDME

Download         Length: 300 bp

>T36758 NZ_AP023174:c2648061-2647762 [Paraburkholderia sp. PGU16]
ATGCCGAGCATCCGCACTACCGATGTATTTGACCACTGGTTTGTTCGCATCCGTGATTTACGTGCGCGCGTGCGAGTGCA
GGCGCGGATCGACAGGCTCGCTATGGGCAACCCCGGCGACCATAAGAGCGTTGGCGCAGGTGTCACCGAATTGCGGATCG
ATTACGGTCCCGGCTACCGGGTCTACTACACCCAGCGAGGGTCGATTCTGGTTGTCCTCTTGTGCGGCGGGGACAAATCG
TCCCAACGGGACGACATTGCCCAAGCCAAGGATCTCGCTGCGAACCTCGATATGGAGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10700.14 Da        Isoelectric Point: 6.7194

>AT36758 WP_180720143.1 NZ_AP023174:c2647758-2647465 [Paraburkholderia sp. PGU16]
MPKTKTTAWDSAEHLRTEEEMAAYLDACLEEAGDDPRFIAHALGVIARARGMSQLARETGVKRESLYRALSGEGNPEFAT
IWKVVRALGIRLHASTT

Download         Length: 294 bp

>AT36758 NZ_AP023174:c2647758-2647465 [Paraburkholderia sp. PGU16]
ATGCCTAAAACCAAGACGACCGCTTGGGACTCCGCCGAACATCTTCGCACCGAAGAGGAAATGGCGGCCTATCTCGATGC
ATGCCTCGAAGAAGCGGGTGATGACCCTCGATTCATCGCTCATGCTCTGGGTGTTATCGCGCGTGCCCGTGGCATGTCGC
AACTTGCACGCGAAACCGGTGTGAAGCGCGAAAGCCTGTACCGCGCTTTGTCTGGCGAAGGGAACCCGGAGTTCGCAACG
ATCTGGAAGGTCGTCCGGGCGCTCGGTATTCGACTGCATGCATCGACTACATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References