Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-StbC
Location 1574864..1575524 Replicon chromosome
Accession NZ_AP023174
Organism Paraburkholderia sp. PGU16

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PPGU16_RS07045 Protein ID WP_180722277.1
Coordinates 1575096..1575524 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PPGU16_RS07040 Protein ID WP_180722276.1
Coordinates 1574864..1575109 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PPGU16_RS07015 1570458..1570970 - 513 WP_180722271.1 Spy/CpxP family protein refolding chaperone -
PPGU16_RS07020 1571124..1572008 + 885 WP_180722272.1 LysR family transcriptional regulator -
PPGU16_RS07025 1572141..1572605 + 465 WP_180722273.1 Lrp/AsnC family transcriptional regulator -
PPGU16_RS07030 1572813..1573910 + 1098 WP_180722274.1 saccharopine dehydrogenase NADP-binding domain-containing protein -
PPGU16_RS07035 1574074..1574694 - 621 WP_180722275.1 ATP-binding protein -
PPGU16_RS07040 1574864..1575109 + 246 WP_180722276.1 DNA-binding protein Antitoxin
PPGU16_RS07045 1575096..1575524 + 429 WP_180722277.1 type II toxin-antitoxin system VapC family toxin Toxin
PPGU16_RS07050 1575622..1576095 + 474 WP_180722278.1 hypothetical protein -
PPGU16_RS07055 1576299..1577276 + 978 WP_180722279.1 magnesium/cobalt transporter CorA -
PPGU16_RS07060 1577319..1577957 - 639 WP_180722280.1 LysE family translocator -
PPGU16_RS07065 1578509..1579465 + 957 WP_180722281.1 sugar ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15698.82 Da        Isoelectric Point: 6.9897

>T36757 WP_180722277.1 NZ_AP023174:1575096-1575524 [Paraburkholderia sp. PGU16]
VYLIDTNVISEMRKSSRANPGVQAFFETAREGGHRLYLSVVTVGELRRGVDLIRHRGDKFQALRLEGWLDTIIDSFSSHI
LNVGTDVAQTWGHLRVPDPAHSLDKLIAATALIYNLTVVTRNVADFDGTGAQVLNPFRALDA

Download         Length: 429 bp

>T36757 NZ_AP023174:1575096-1575524 [Paraburkholderia sp. PGU16]
GTGTATTTGATTGACACCAATGTAATCAGCGAAATGCGCAAGAGCAGCCGCGCCAACCCCGGCGTGCAGGCTTTCTTTGA
AACGGCGAGGGAAGGCGGGCATCGCCTGTATCTTTCGGTCGTGACCGTTGGCGAGTTGCGCCGTGGCGTCGACCTGATCC
GGCATCGGGGCGACAAATTCCAGGCGTTGCGCCTCGAAGGCTGGCTCGACACGATCATCGACTCCTTCAGCAGCCACATT
CTGAACGTCGGCACGGACGTCGCGCAGACATGGGGCCATCTGCGCGTGCCGGATCCCGCGCATTCGCTGGACAAACTGAT
CGCGGCGACGGCCCTGATCTACAACCTGACCGTCGTGACGCGCAACGTGGCAGACTTCGATGGCACGGGCGCGCAGGTGC
TGAACCCGTTCCGGGCCCTGGACGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8926.88 Da        Isoelectric Point: 4.2208

>AT36757 WP_180722276.1 NZ_AP023174:1574864-1575109 [Paraburkholderia sp. PGU16]
MANLLVRGLDDALVQNLREQAAAHGRSVEAEHREILAQALFQPKKLSFAEWLMSMPDVGDDADFERRNDATDDSGGPGVF
D

Download         Length: 246 bp

>AT36757 NZ_AP023174:1574864-1575109 [Paraburkholderia sp. PGU16]
ATGGCAAATCTTTTGGTCCGAGGTCTGGACGATGCGCTGGTGCAGAACCTGCGTGAACAGGCCGCGGCTCACGGGCGCAG
CGTCGAAGCAGAGCATCGGGAAATCCTGGCGCAGGCGCTTTTTCAGCCCAAAAAGCTCAGCTTCGCGGAGTGGCTGATGA
GCATGCCCGACGTCGGCGATGACGCCGATTTCGAGCGCCGCAACGACGCAACTGACGATAGCGGGGGACCGGGTGTATTT
GATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References