Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 4431832..4432904 Replicon chromosome
Accession NZ_AP023172
Organism Rhodococcus qingshengii strain CS98

Toxin (Protein)


Gene name phRel Uniprot ID A0A7I8B7W4
Locus tag RQCS_RS20135 Protein ID WP_064687454.1
Coordinates 4432050..4432904 (-) Length 285 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7I8B8G7
Locus tag RQCS_RS20130 Protein ID WP_064687453.1
Coordinates 4431832..4432047 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RQCS_RS20100 4426966..4427736 + 771 Protein_3956 site-specific integrase -
RQCS_RS20105 4427902..4428813 - 912 WP_143541184.1 hypothetical protein -
RQCS_RS20110 4429207..4429518 + 312 WP_064687450.1 hypothetical protein -
RQCS_RS20115 4429529..4429825 + 297 WP_064687451.1 hypothetical protein -
RQCS_RS20120 4430215..4430808 + 594 WP_156665913.1 hypothetical protein -
RQCS_RS20125 4430839..4431015 - 177 WP_156665914.1 hypothetical protein -
RQCS_RS20130 4431832..4432047 - 216 WP_064687453.1 hypothetical protein Antitoxin
RQCS_RS20135 4432050..4432904 - 855 WP_064687454.1 hypothetical protein Toxin
RQCS_RS20140 4433340..4433843 - 504 WP_064687455.1 hypothetical protein -
RQCS_RS20145 4433840..4433998 - 159 WP_156665915.1 hypothetical protein -
RQCS_RS20150 4435078..4435326 + 249 WP_156665916.1 hypothetical protein -
RQCS_RS20155 4436923..4437318 - 396 WP_064687457.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4426963..4483864 56901


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(72-169)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 285 a.a.        Molecular weight: 32397.72 Da        Isoelectric Point: 5.9984

>T36755 WP_064687454.1 NZ_AP023172:c4432904-4432050 [Rhodococcus qingshengii]
MLINDKLPWSKRQLKKLGYALLSDGTVPQNCPDYDSVMLWHHELAAEVARVLRGAISNVNWNNGDITCHVTSRGKTVDTL
IQKLERSSITLDVIQDLAGVRIDGNFNTAQQTQLAEALGKYFDVDERGFRDLRSTPHSGYRAFHLWLRLPAGRVEVQIRT
EGQSEWANAYERLGDHLGRGIRYGEEADVPGAQEVVEAFHQLSFELAAIEHKVMMVHFAQTLPPDRIAKVIQTTPDPVQR
AEFIELQQVLVDAESERQAIFTSHENYLVKMRRLRRMIEDLEEV

Download         Length: 855 bp

>T36755 NZ_AP023172:c4432904-4432050 [Rhodococcus qingshengii]
ATGCTCATCAACGACAAGCTTCCGTGGTCGAAGCGTCAGCTAAAGAAACTTGGCTATGCGCTTCTGTCGGACGGGACCGT
GCCGCAAAATTGTCCAGATTACGACTCCGTCATGCTTTGGCACCACGAGTTGGCTGCTGAGGTTGCGCGCGTCCTGCGCG
GAGCGATCAGTAACGTGAACTGGAACAACGGTGACATCACCTGCCATGTAACATCTCGCGGAAAAACCGTAGACACTTTG
ATACAGAAACTTGAGCGAAGCAGCATCACCCTGGATGTGATCCAAGATCTCGCCGGTGTTCGAATCGATGGCAATTTCAA
TACCGCTCAGCAGACGCAGCTGGCCGAGGCGCTCGGGAAATACTTCGATGTGGATGAACGTGGATTTCGAGATCTTCGGT
CCACCCCACACAGCGGATATCGCGCTTTTCACCTCTGGTTGCGACTCCCTGCGGGGAGAGTGGAAGTTCAGATCCGAACC
GAAGGTCAAAGCGAGTGGGCCAACGCGTATGAACGGCTGGGGGATCATCTTGGCCGAGGGATCCGCTATGGCGAAGAAGC
TGACGTCCCGGGGGCGCAGGAGGTTGTCGAAGCGTTCCACCAGCTGTCCTTTGAGCTAGCCGCGATTGAACACAAAGTGA
TGATGGTCCATTTTGCCCAGACACTGCCACCCGACCGAATTGCGAAGGTAATCCAGACCACACCGGACCCGGTTCAGCGA
GCCGAATTCATTGAGTTGCAGCAGGTTCTGGTCGATGCCGAGAGTGAGCGCCAGGCGATATTCACCTCTCATGAGAACTA
TCTTGTGAAGATGCGGAGGCTGCGTCGTATGATCGAGGATCTAGAGGAGGTCTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8234.29 Da        Isoelectric Point: 5.0916

>AT36755 WP_064687453.1 NZ_AP023172:c4432047-4431832 [Rhodococcus qingshengii]
MPNYVIEFNRKTRDRRVTEFDDAREAMLRRLKLESDRTDSNVEIVALTSDSLEALMSTHARYFTGAELIAP

Download         Length: 216 bp

>AT36755 NZ_AP023172:c4432047-4431832 [Rhodococcus qingshengii]
ATGCCAAACTATGTCATCGAGTTCAACCGCAAGACGCGCGATCGGCGGGTCACCGAGTTCGACGATGCTCGTGAGGCAAT
GCTGCGCAGATTGAAGCTGGAGTCCGATCGTACCGATTCCAATGTTGAGATCGTCGCCCTCACCAGCGACTCTCTCGAAG
CATTGATGTCGACACACGCTCGGTACTTCACAGGCGCTGAGCTAATTGCTCCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I8B7W4

Antitoxin

Source ID Structure
AlphaFold DB A0A7I8B8G7

References