Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 4078400..4079319 Replicon chromosome
Accession NZ_AP023089
Organism Bacillus paralicheniformis strain RSC-2

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A6I7TYV7
Locus tag KI219_RS20330 Protein ID WP_023856735.1
Coordinates 4078573..4079319 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID A0A6I7TM13
Locus tag KI219_RS20325 Protein ID WP_023856734.1
Coordinates 4078400..4078573 (-) Length 58 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI219_RS20305 (RSC2_04186) 4073825..4074922 + 1098 WP_025811596.1 mannonate dehydratase -
KI219_RS20310 (RSC2_04187) 4074898..4075746 + 849 WP_023856787.1 SDR family oxidoreductase -
KI219_RS20315 (RSC2_04188) 4075772..4076785 + 1014 WP_035338915.1 zinc-binding alcohol dehydrogenase family protein -
KI219_RS20320 (RSC2_04189) 4076837..4078108 + 1272 WP_035338913.1 MFS transporter -
KI219_RS21870 4078175..4078306 - 132 WP_023856733.1 hypothetical protein -
KI219_RS20325 (RSC2_04190) 4078400..4078573 - 174 WP_023856734.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
KI219_RS20330 (RSC2_04191) 4078573..4079319 - 747 WP_023856735.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KI219_RS20335 (RSC2_04192) 4079429..4080427 - 999 WP_075212749.1 inorganic phosphate transporter -
KI219_RS20340 (RSC2_04193) 4080440..4081057 - 618 WP_023856737.1 DUF47 domain-containing protein -
KI219_RS20345 (RSC2_04194) 4081390..4083147 + 1758 WP_026579843.1 gamma-glutamyltransferase -
KI219_RS20350 (RSC2_04195) 4083282..4083926 + 645 WP_003180888.1 YesL family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-238)

Antitoxin

(1-57)


Sequences


Toxin        


Download         Length: 249 a.a.        Molecular weight: 29421.87 Da        Isoelectric Point: 4.6015

>T36738 WP_023856735.1 NZ_AP023089:c4079319-4078573 [Bacillus paralicheniformis]
MLLFYQFLVWLIVLALALYVAAVWRFEKKLTEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLERKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEDGDD

Download         Length: 747 bp

>T36738 NZ_AP023089:c4079319-4078573 [Bacillus paralicheniformis]
ATGCTGCTATTTTATCAATTCCTTGTTTGGCTCATTGTATTGGCGCTGGCTCTGTATGTGGCTGCCGTGTGGCGTTTTGA
AAAAAAGCTCACCGAAAAAACGGTCGCGATCCGAAAAACTTGGTACCTGCTTTATGTTATCGGCGCCGTGATTTATTGGA
CGCACGATCCGCAGTCGATTTTCACAAACCCGCTTCATTACTTGATCGTTGCCGTTTTTTTCACGCTGACAGACGCTTTT
ATTTTCTTAAACGCTTACTTTAAAAAGCTCGGCAGCTCCGAACTCGCGACAGACACAAGAATGCTTCTCGAAGAAAACAA
CGACCTCCTCCACACATATCAAAACAGGCTGAAAACGTTTCAATACCTATTGAAAAATGAACCGATCCACATCTATTATG
GAAATATAGAAGCATATGCAGAAGGGATCGAAAAGCTCATCAAACGATTTGCCGAAAAAATGAATATATCCGCTGCACTT
TGCGAATATAATTCAGAAGAAAGCAAGGATCATTTGCTTGAGCATATGGAAAACCGCTTCGATGTTCAAGAAAAGCTTGA
GCGCAAAGACGTTTATTATGAAGAAAATGGAAAAATGGTCCTCATTCCTTTTTCCATCCACGATTTTGACTATGTCATGA
AGTTAACCTCAGAAGACCTTGTCACAGAATTTGACTACCTCCTGTTTACTTCTTTAACAAGCATCTATGATCTTCTGCTA
CCAAACGAAGAGGACGGTGACGACTGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6897.99 Da        Isoelectric Point: 10.8356

>AT36738 WP_023856734.1 NZ_AP023089:c4078573-4078400 [Bacillus paralicheniformis]
MEPAFQQDHESAKKRLAFKMFKKQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA

Download         Length: 174 bp

>AT36738 NZ_AP023089:c4078573-4078400 [Bacillus paralicheniformis]
ATGGAGCCTGCTTTTCAGCAAGACCATGAAAGCGCAAAAAAGCGCCTCGCCTTTAAAATGTTTAAAAAGCAATCCAAAAC
CAATATCGCGAAATACGAAGTCAGCCCCCATACCGAACGGATTTTCCGGCAAAACGAACGGCTGATCGGCGAGTATAAAA
GAAAAAAAGCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A6I7TYV7


Antitoxin

Source ID Structure
AlphaFold DB A0A6I7TM13

References