Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
| Location | 2329422..2330341 | Replicon | chromosome |
| Accession | NZ_AP023088 | ||
| Organism | Bacillus paralicheniformis strain RSC-1 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | A0A6I7TYV7 |
| Locus tag | KI220_RS11615 | Protein ID | WP_023856735.1 |
| Coordinates | 2329595..2330341 (-) | Length | 249 a.a. |
Antitoxin (Protein)
| Gene name | spoIISB | Uniprot ID | A0A6I7TM13 |
| Locus tag | KI220_RS11610 | Protein ID | WP_023856734.1 |
| Coordinates | 2329422..2329595 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KI220_RS11590 (RSC1_02319) | 2324847..2325944 | + | 1098 | WP_025811596.1 | mannonate dehydratase | - |
| KI220_RS11595 (RSC1_02320) | 2325920..2326768 | + | 849 | WP_023856787.1 | SDR family oxidoreductase | - |
| KI220_RS11600 (RSC1_02321) | 2326794..2327807 | + | 1014 | WP_035338915.1 | zinc-binding alcohol dehydrogenase family protein | - |
| KI220_RS11605 (RSC1_02322) | 2327859..2329130 | + | 1272 | WP_035338913.1 | MFS transporter | - |
| KI220_RS21670 | 2329197..2329328 | - | 132 | WP_023856733.1 | hypothetical protein | - |
| KI220_RS11610 (RSC1_02323) | 2329422..2329595 | - | 174 | WP_023856734.1 | type II toxin-antitoxin system SpoIISB family antitoxin | Antitoxin |
| KI220_RS11615 (RSC1_02324) | 2329595..2330341 | - | 747 | WP_023856735.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| KI220_RS11620 (RSC1_02325) | 2330451..2331449 | - | 999 | WP_075212749.1 | inorganic phosphate transporter | - |
| KI220_RS11625 (RSC1_02326) | 2331462..2332079 | - | 618 | WP_023856737.1 | DUF47 domain-containing protein | - |
| KI220_RS11630 (RSC1_02327) | 2332412..2334169 | + | 1758 | WP_026579843.1 | gamma-glutamyltransferase | - |
| KI220_RS11635 (RSC1_02328) | 2334304..2334948 | + | 645 | WP_003180888.1 | YesL family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29421.87 Da Isoelectric Point: 4.6015
>T36736 WP_023856735.1 NZ_AP023088:c2330341-2329595 [Bacillus paralicheniformis]
MLLFYQFLVWLIVLALALYVAAVWRFEKKLTEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLERKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEDGDD
MLLFYQFLVWLIVLALALYVAAVWRFEKKLTEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLERKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEDGDD
Download Length: 747 bp
>T36736 NZ_AP023088:c2330341-2329595 [Bacillus paralicheniformis]
ATGCTGCTATTTTATCAATTCCTTGTTTGGCTCATTGTATTGGCGCTGGCTCTGTATGTGGCTGCCGTGTGGCGTTTTGA
AAAAAAGCTCACCGAAAAAACGGTCGCGATCCGAAAAACTTGGTACCTGCTTTATGTTATCGGCGCCGTGATTTATTGGA
CGCACGATCCGCAGTCGATTTTCACAAACCCGCTTCATTACTTGATCGTTGCCGTTTTTTTCACGCTGACAGACGCTTTT
ATTTTCTTAAACGCTTACTTTAAAAAGCTCGGCAGCTCCGAACTCGCGACAGACACAAGAATGCTTCTCGAAGAAAACAA
CGACCTCCTCCACACATATCAAAACAGGCTGAAAACGTTTCAATACCTATTGAAAAATGAACCGATCCACATCTATTATG
GAAATATAGAAGCATATGCAGAAGGGATCGAAAAGCTCATCAAACGATTTGCCGAAAAAATGAATATATCCGCTGCACTT
TGCGAATATAATTCAGAAGAAAGCAAGGATCATTTGCTTGAGCATATGGAAAACCGCTTCGATGTTCAAGAAAAGCTTGA
GCGCAAAGACGTTTATTATGAAGAAAATGGAAAAATGGTCCTCATTCCTTTTTCCATCCACGATTTTGACTATGTCATGA
AGTTAACCTCAGAAGACCTTGTCACAGAATTTGACTACCTCCTGTTTACTTCTTTAACAAGCATCTATGATCTTCTGCTA
CCAAACGAAGAGGACGGTGACGACTGA
ATGCTGCTATTTTATCAATTCCTTGTTTGGCTCATTGTATTGGCGCTGGCTCTGTATGTGGCTGCCGTGTGGCGTTTTGA
AAAAAAGCTCACCGAAAAAACGGTCGCGATCCGAAAAACTTGGTACCTGCTTTATGTTATCGGCGCCGTGATTTATTGGA
CGCACGATCCGCAGTCGATTTTCACAAACCCGCTTCATTACTTGATCGTTGCCGTTTTTTTCACGCTGACAGACGCTTTT
ATTTTCTTAAACGCTTACTTTAAAAAGCTCGGCAGCTCCGAACTCGCGACAGACACAAGAATGCTTCTCGAAGAAAACAA
CGACCTCCTCCACACATATCAAAACAGGCTGAAAACGTTTCAATACCTATTGAAAAATGAACCGATCCACATCTATTATG
GAAATATAGAAGCATATGCAGAAGGGATCGAAAAGCTCATCAAACGATTTGCCGAAAAAATGAATATATCCGCTGCACTT
TGCGAATATAATTCAGAAGAAAGCAAGGATCATTTGCTTGAGCATATGGAAAACCGCTTCGATGTTCAAGAAAAGCTTGA
GCGCAAAGACGTTTATTATGAAGAAAATGGAAAAATGGTCCTCATTCCTTTTTCCATCCACGATTTTGACTATGTCATGA
AGTTAACCTCAGAAGACCTTGTCACAGAATTTGACTACCTCCTGTTTACTTCTTTAACAAGCATCTATGATCTTCTGCTA
CCAAACGAAGAGGACGGTGACGACTGA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6897.99 Da Isoelectric Point: 10.8356
>AT36736 WP_023856734.1 NZ_AP023088:c2329595-2329422 [Bacillus paralicheniformis]
MEPAFQQDHESAKKRLAFKMFKKQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA
MEPAFQQDHESAKKRLAFKMFKKQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA
Download Length: 174 bp
>AT36736 NZ_AP023088:c2329595-2329422 [Bacillus paralicheniformis]
ATGGAGCCTGCTTTTCAGCAAGACCATGAAAGCGCAAAAAAGCGCCTCGCCTTTAAAATGTTTAAAAAGCAATCCAAAAC
CAATATCGCGAAATACGAAGTCAGCCCCCATACCGAACGGATTTTCCGGCAAAACGAACGGCTGATCGGCGAGTATAAAA
GAAAAAAAGCTTAA
ATGGAGCCTGCTTTTCAGCAAGACCATGAAAGCGCAAAAAAGCGCCTCGCCTTTAAAATGTTTAAAAAGCAATCCAAAAC
CAATATCGCGAAATACGAAGTCAGCCCCCATACCGAACGGATTTTCCGGCAAAACGAACGGCTGATCGGCGAGTATAAAA
GAAAAAAAGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6I7TYV7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6I7TM13 |