Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1987904..1988393 Replicon chromosome
Accession NZ_AP023082
Organism Francisella halioticida strain UTH170823

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag fh0823_RS11205 Protein ID WP_212789614.1
Coordinates 1988124..1988393 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag fh0823_RS11200 Protein ID WP_212789613.1
Coordinates 1987904..1988122 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
fh0823_RS11175 (fh0823_24080) 1983690..1984328 - 639 WP_212789608.1 ParA family protein -
fh0823_RS11180 (fh0823_24090) 1984521..1985078 + 558 WP_212789609.1 hypothetical protein -
fh0823_RS11185 (fh0823_24100) 1985232..1985909 + 678 WP_212789610.1 iron-containing redox enzyme family protein -
fh0823_RS11190 (fh0823_24110) 1985906..1986976 + 1071 WP_212789611.1 DUF3419 family protein -
fh0823_RS11195 (fh0823_24120) 1986966..1987754 + 789 WP_212789612.1 GNAT family N-acetyltransferase -
fh0823_RS11200 (fh0823_24130) 1987904..1988122 + 219 WP_212789613.1 DUF6290 family protein Antitoxin
fh0823_RS11205 (fh0823_24140) 1988124..1988393 + 270 WP_212789614.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
fh0823_RS11210 (fh0823_24150) 1988386..1988955 + 570 WP_212789615.1 recombinase family protein -
fh0823_RS11215 (fh0823_24160) 1989017..1989598 + 582 WP_212789616.1 hypothetical protein -
fh0823_RS11220 (fh0823_24170) 1989783..1990607 - 825 WP_212789617.1 IS3 family transposase -
fh0823_RS11225 (fh0823_24180) 1990685..1991842 + 1158 WP_212789060.1 IS3 family transposase -
fh0823_RS11230 (fh0823_24190) 1991948..1992241 - 294 WP_212788884.1 hypothetical protein -
fh0823_RS11235 (fh0823_24200) 1992389..1992676 + 288 WP_212789618.1 hypothetical protein -
fh0823_RS11240 (fh0823_24210) 1992666..1992974 + 309 WP_212789619.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Protein of unknown function DUF6290

(3-70)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10427.36 Da        Isoelectric Point: 10.7236

>T36734 WP_212789614.1 NZ_AP023082:1988124-1988393 [Francisella halioticida]
MWKISWSNKARKQLTKLDIDIQKQIAKFIDEKLILCSEPQTLGKRLSGATLGKFYRFRIGDYRLICDVQKQSITITVLKI
GHRKEVYRG

Download         Length: 270 bp

>T36734 NZ_AP023082:1988124-1988393 [Francisella halioticida]
ATGTGGAAAATATCTTGGAGCAACAAAGCCAGAAAACAATTAACTAAATTAGATATAGATATCCAAAAACAAATAGCTAA
ATTTATAGATGAAAAGCTAATACTCTGTTCTGAACCTCAAACTTTAGGTAAAAGATTAAGTGGAGCTACATTAGGAAAGT
TCTATAGATTTAGAATTGGTGACTATAGACTTATATGTGATGTACAGAAACAATCAATTACTATTACTGTTTTAAAAATA
GGACATCGAAAAGAGGTATATCGTGGGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8384.45 Da        Isoelectric Point: 4.2290

>AT36734 WP_212789613.1 NZ_AP023082:1987904-1988122 [Francisella halioticida]
MAQVRLNDDIMTRLKHLADETGRSMSFYIREAVESKLEDLEDIYLAEKALEDIRAGNDELVSWEDVKKELNL

Download         Length: 219 bp

>AT36734 NZ_AP023082:1987904-1988122 [Francisella halioticida]
ATGGCTCAGGTTAGATTGAATGATGACATAATGACAAGATTAAAACACCTTGCCGATGAAACAGGAAGAAGTATGTCTTT
TTATATTAGAGAAGCTGTTGAATCAAAACTAGAAGATTTAGAAGATATTTATCTAGCTGAAAAAGCTTTAGAAGATATTA
GAGCTGGTAACGATGAACTAGTTTCTTGGGAAGACGTAAAAAAAGAGTTGAATCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References