36721

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 3646461..3647049 Replicon chromosome
Accession NZ_AP023077
Organism Acinetobacter baumannii strain OCU_Ac16a

Toxin (Protein)


Gene name brnT Uniprot ID N8SM64
Locus tag OCUAC_RS17455 Protein ID WP_000438825.1
Coordinates 3646762..3647049 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID D3JXQ4
Locus tag OCUAC_RS17450 Protein ID WP_004728120.1
Coordinates 3646461..3646775 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCUAC_RS17415 3641917..3643392 - 1476 WP_000052512.1 ABC-F type ribosomal protection protein Msr(E) -
OCUAC_RS17420 3643885..3644157 - 273 WP_000369781.1 helix-turn-helix domain-containing protein -
OCUAC_RS17425 3644150..3644470 - 321 WP_000897307.1 type II toxin-antitoxin system RelE/ParE family toxin -
OCUAC_RS17430 3644610..3645029 + 420 WP_001180106.1 SMI1/KNR4 family protein -
OCUAC_RS17435 3645109..3645390 - 282 WP_000985609.1 putative addiction module antidote protein -
OCUAC_RS17440 3645391..3645693 - 303 WP_000286964.1 type II toxin-antitoxin system RelE/ParE family toxin -
OCUAC_RS17445 3645842..3646372 + 531 WP_000172759.1 hypothetical protein -
OCUAC_RS17450 3646461..3646775 - 315 WP_004728120.1 BrnA antitoxin family protein Antitoxin
OCUAC_RS17455 3646762..3647049 - 288 WP_000438825.1 BrnT family toxin Toxin
OCUAC_RS17460 3647279..3647884 - 606 WP_000447788.1 LysE family translocator -
OCUAC_RS17465 3647934..3648762 - 829 Protein_3406 AraC family transcriptional regulator -
OCUAC_RS17470 3648890..3649501 - 612 Protein_3407 IS1-like element ISAba3 family transposase -
OCUAC_RS17475 3649565..3650269 + 705 WP_001067790.1 IS6-like element IS1008 family transposase -
OCUAC_RS17480 3650323..3650580 - 258 Protein_3409 WYL domain-containing protein -
OCUAC_RS17485 3650789..3651118 + 330 WP_000506885.1 DUF4236 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3645842..3656370 10528
- inside IScluster/Tn - - 3649205..3657121 7916


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11304.70 Da        Isoelectric Point: 5.6205

>T36721 WP_000438825.1 NZ_AP023077:c3647049-3646762 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTDGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T36721 NZ_AP023077:c3647049-3646762 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGACATACCGATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGGCAAGTGACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12200.86 Da        Isoelectric Point: 8.4628

>AT36721 WP_004728120.1 NZ_AP023077:c3646775-3646461 [Acinetobacter baumannii]
MSMVRYSRKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSSAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT36721 NZ_AP023077:c3646775-3646461 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACGCAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACCGATTGGAGCAGTGCTGTACGCC
AAAATCAATTTTACCGCCCAGTGAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGAATGAATGAAATTTTACGGGATGCTATGCTGAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8TVQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8TRI9

References