Detailed information of TA system TA036718

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2524234..2524913
• Replicon: chromosome
• Accession: NZ_AP023077
• Organism: Acinetobacter baumannii strain OCU_Ac16a

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: OCUAC_RS12055
• Protein ID: WP_000838146.1
• Coordinates: 2524731..2524913 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: OCUAC_RS12050
• Protein ID: WP_000966688.1
• Coordinates: 2524234..2524638 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCUAC_RS12040	2523190..2523453	-	264	WP_001275792.1	hypothetical protein	-
OCUAC_RS12045	2523455..2524135	-	681	WP_000721572.1	hypothetical protein	-
OCUAC_RS12050	2524234..2524638	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
OCUAC_RS12055	2524731..2524913	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
OCUAC_RS12060	2525239..2525754	-	516	WP_072690123.1	hypothetical protein	-
OCUAC_RS12065	2525824..2526741	-	918	WP_072690121.1	hypothetical protein	-
OCUAC_RS12070	2526838..2528070	-	1233	WP_180635454.1	phage tail protein	-
OCUAC_RS12075	2528070..2528420	-	351	WP_072690117.1	hypothetical protein	-
OCUAC_RS12080	2528489..2528887	-	399	WP_072690115.1	hypothetical protein	-
OCUAC_RS12085	2528889..2529257	-	369	WP_072690113.1	hypothetical protein	-
OCUAC_RS12090	2529229..2529633	-	405	WP_005135106.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2510594..2560803	50209

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T36718 WP_000838146.1 NZ_AP023077:c2524913-2524731 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T36718 NZ_AP023077:c2524913-2524731 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT36718 WP_000966688.1 NZ_AP023077:c2524638-2524234 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT36718 NZ_AP023077:c2524638-2524234 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6