Detailed information of TA system TA036717

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1194151..1194830
• Replicon: chromosome
• Accession: NZ_AP023077
• Organism: Acinetobacter baumannii strain OCU_Ac16a

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: OCUAC_RS05670
• Protein ID: WP_000838146.1
• Coordinates: 1194151..1194333 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: OCUAC_RS05675
• Protein ID: WP_000966688.1
• Coordinates: 1194426..1194830 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCUAC_RS05635	1189431..1189835	+	405	WP_005135106.1	hypothetical protein	-
OCUAC_RS05640	1189807..1190175	+	369	WP_072690113.1	hypothetical protein	-
OCUAC_RS05645	1190177..1190575	+	399	WP_072690115.1	hypothetical protein	-
OCUAC_RS05650	1190644..1190994	+	351	WP_072690117.1	hypothetical protein	-
OCUAC_RS05655	1190994..1192226	+	1233	WP_072690119.1	hypothetical protein	-
OCUAC_RS05660	1192323..1193240	+	918	WP_072690121.1	hypothetical protein	-
OCUAC_RS05665	1193310..1193825	+	516	WP_072690123.1	hypothetical protein	-
OCUAC_RS05670	1194151..1194333	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
OCUAC_RS05675	1194426..1194830	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
OCUAC_RS05680	1194929..1195609	+	681	WP_000721572.1	hypothetical protein	-
OCUAC_RS05685	1195611..1195874	+	264	WP_001275792.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1167116..1212365	45249

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T36717 WP_000838146.1 NZ_AP023077:1194151-1194333 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T36717 NZ_AP023077:1194151-1194333 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT36717 WP_000966688.1 NZ_AP023077:1194426-1194830 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT36717 NZ_AP023077:1194426-1194830 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6