Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 268..731 Replicon plasmid pMTY16691
Accession NZ_AP023076
Organism Neisseria gonorrhoeae strain TUM16691

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag HT073_RS11385 Protein ID WP_003690225.1
Coordinates 453..731 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag HT073_RS11380 Protein ID WP_003690223.1
Coordinates 268..453 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HT073_RS11375 20..265 + 246 WP_003690221.1 hypothetical protein -
HT073_RS11380 268..453 + 186 WP_003690223.1 DUF5397 family protein Antitoxin
HT073_RS11385 453..731 + 279 WP_003690225.1 endoribonuclease VapD Toxin
HT073_RS11390 709..978 - 270 WP_003692166.1 hypothetical protein -
HT073_RS11395 1010..1597 - 588 WP_003692168.1 B protein -
HT073_RS11400 1681..2310 - 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -
HT073_RS11405 2295..2486 - 192 WP_003690218.1 plasmid mobilization relaxosome protein MobC -
HT073_RS11590 2754..2978 + 225 WP_025455920.1 hypothetical protein -
HT073_RS11410 3148..3930 + 783 WP_010359605.1 replication initiation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4153 4153


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T36715 WP_003690225.1 NZ_AP023076:453-731 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

>T36715 NZ_AP023076:453-731 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT36715 WP_003690223.1 NZ_AP023076:268-453 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp

>AT36715 NZ_AP023076:268-453 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References