Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1364..1827 Replicon plasmid pMTY15753
Accession NZ_AP023074
Organism Neisseria gonorrhoeae strain TUM15753

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag HT081_RS11595 Protein ID WP_003690225.1
Coordinates 1364..1642 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag HT081_RS11600 Protein ID WP_003690223.1
Coordinates 1642..1827 (-) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HT081_RS11585 444..1085 + 642 WP_003690229.1 Cryptic plasmid protein B -
HT081_RS11590 1117..1386 + 270 WP_003692166.1 hypothetical protein -
HT081_RS11595 1364..1642 - 279 WP_003690225.1 endoribonuclease VapD Toxin
HT081_RS11600 1642..1827 - 186 WP_003690223.1 DUF5397 family protein Antitoxin
HT081_RS11605 1830..2075 - 246 WP_003690221.1 hypothetical protein -
HT081_RS11610 2072..2314 - 243 WP_003690220.1 HTH domain-containing protein -
HT081_RS11615 2318..3100 - 783 WP_010359605.1 replication initiation protein -
HT081_RS11620 3270..3494 - 225 WP_025455920.1 hypothetical protein -
HT081_RS11625 3762..3953 + 192 WP_003690218.1 plasmid mobilization relaxosome protein MobC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4207 4207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T36713 WP_003690225.1 NZ_AP023074:c1642-1364 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

>T36713 NZ_AP023074:c1642-1364 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT36713 WP_003690223.1 NZ_AP023074:c1827-1642 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp

>AT36713 NZ_AP023074:c1827-1642 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References