Detailed information of TA system TA036712

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1628680..1629366
• Replicon: chromosome
• Accession: NZ_AP023073
• Organism: Neisseria gonorrhoeae strain TUM15753

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: HT081_RS08385
• Protein ID: WP_003689143.1
• Coordinates: 1629184..1629366 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: HT081_RS08380
• Protein ID: WP_003691454.1
• Coordinates: 1628680..1629081 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HT081_RS08335	1624379..1624540	-	162	WP_003693867.1	hypothetical protein	-
HT081_RS08340	1624537..1624815	-	279	WP_003691529.1	hypothetical protein	-
HT081_RS08345	1624968..1625300	-	333	WP_003687946.1	hypothetical protein	-
HT081_RS08350	1625441..1625728	-	288	WP_050155496.1	hypothetical protein	-
HT081_RS08355	1625725..1626201	-	477	WP_012504141.1	hypothetical protein	-
HT081_RS08360	1626234..1626429	-	196	Protein_1614	hypothetical protein	-
HT081_RS08365	1626618..1627400	+	783	WP_003689146.1	hypothetical protein	-
HT081_RS08370	1627489..1627905	-	417	WP_003700378.1	hypothetical protein	-
HT081_RS08375	1627914..1628498	-	585	WP_003693477.1	SocA family protein	-
HT081_RS08380	1628680..1629081	-	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HT081_RS08385	1629184..1629366	-	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
HT081_RS08390	1629536..1630354	-	819	WP_172760554.1	DUF3037 domain-containing protein	-
HT081_RS08395	1630629..1631384	-	756	WP_003693472.1	LexA family transcriptional regulator	-
HT081_RS08400	1631521..1631706	+	186	WP_002238713.1	Cro/Cl family transcriptional regulator	-
HT081_RS08405	1631796..1631951	+	156	WP_003689578.1	hypothetical protein	-
HT081_RS08410	1631928..1632116	-	189	WP_003691445.1	hypothetical protein	-
HT081_RS08415	1632289..1632516	+	228	WP_003698261.1	helix-turn-helix domain-containing protein	-
HT081_RS08420	1632634..1633699	+	1066	Protein_1626	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1612319..1647254	34935

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T36712 WP_003689143.1 NZ_AP023073:c1629366-1629184 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T36712 NZ_AP023073:c1629366-1629184 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT36712 WP_003691454.1 NZ_AP023073:c1629081-1628680 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT36712 NZ_AP023073:c1629081-1628680 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATTCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2