Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 641503..642158 Replicon chromosome
Accession NZ_AP023073
Organism Neisseria gonorrhoeae strain TUM15753

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag HT081_RS03310 Protein ID WP_003691083.1
Coordinates 641739..642158 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag HT081_RS03305 Protein ID WP_003688410.1
Coordinates 641503..641739 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HT081_RS03270 636638..636925 + 288 WP_003688407.1 hypothetical protein -
HT081_RS03275 636997..638163 + 1167 WP_003693287.1 ADP-forming succinate--CoA ligase subunit beta -
HT081_RS03280 638174..639064 + 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
HT081_RS03285 639447..639833 - 387 Protein_622 transposase -
HT081_RS03290 640045..640473 + 429 WP_010360042.1 helix-turn-helix domain-containing protein -
HT081_RS03295 640478..641056 + 579 WP_003688041.1 IS3 family transposase -
HT081_RS03300 641101..641298 + 198 WP_033910354.1 IS3 family transposase -
HT081_RS03305 641503..641739 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
HT081_RS03310 641739..642158 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
HT081_RS03315 642307..643761 - 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
HT081_RS03320 643758..644459 - 702 WP_003688414.1 lactate utilization protein C -
HT081_RS03325 644456..645235 - 780 WP_003688416.1 (Fe-S)-binding protein -
HT081_RS03330 645383..646924 + 1542 WP_003693283.1 multidrug efflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T36711 WP_003691083.1 NZ_AP023073:641739-642158 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T36711 NZ_AP023073:641739-642158 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT36711 WP_003688410.1 NZ_AP023073:641503-641739 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT36711 NZ_AP023073:641503-641739 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References