Detailed information of TA system TA036710

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1671906..1672592
• Replicon: chromosome
• Accession: NZ_AP023071
• Organism: Neisseria gonorrhoeae strain TUM15748

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: HT078_RS08680
• Protein ID: WP_003689143.1
• Coordinates: 1672410..1672592 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: HT078_RS08675
• Protein ID: WP_003691454.1
• Coordinates: 1671906..1672307 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HT078_RS08630	1667595..1667756	-	162	WP_003693867.1	hypothetical protein	-
HT078_RS08635	1667753..1668031	-	279	WP_003691529.1	hypothetical protein	-
HT078_RS08640	1668184..1668516	-	333	WP_003687946.1	hypothetical protein	-
HT078_RS08645	1668657..1668938	-	282	WP_050165255.1	hypothetical protein	-
HT078_RS08650	1668935..1669411	-	477	WP_012504141.1	hypothetical protein	-
HT078_RS08655	1669444..1669644	-	201	WP_047920246.1	hypothetical protein	-
HT078_RS08660	1669844..1670626	+	783	WP_003689146.1	hypothetical protein	-
HT078_RS08665	1670715..1671131	-	417	WP_003700378.1	hypothetical protein	-
HT078_RS08670	1671140..1671724	-	585	WP_003693477.1	SocA family protein	-
HT078_RS08675	1671906..1672307	-	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HT078_RS08680	1672410..1672592	-	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
HT078_RS08685	1672762..1673580	-	819	WP_172760554.1	DUF3037 domain-containing protein	-
HT078_RS08690	1673855..1674610	-	756	WP_003693472.1	LexA family transcriptional regulator	-
HT078_RS08695	1674747..1674932	+	186	WP_002238713.1	Cro/Cl family transcriptional regulator	-
HT078_RS08700	1675022..1675177	+	156	WP_003689578.1	hypothetical protein	-
HT078_RS08705	1675154..1675342	-	189	WP_003691445.1	hypothetical protein	-
HT078_RS08710	1675515..1675742	+	228	WP_003698261.1	helix-turn-helix domain-containing protein	-
HT078_RS08715	1675860..1676924	+	1065	WP_003689134.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1655534..1690478	34944

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T36710 WP_003689143.1 NZ_AP023071:c1672592-1672410 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T36710 NZ_AP023071:c1672592-1672410 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT36710 WP_003691454.1 NZ_AP023071:c1672307-1671906 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT36710 NZ_AP023071:c1672307-1671906 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATTCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2