Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 599..1062 Replicon plasmid pMTY19853
Accession NZ_AP023068
Organism Neisseria gonorrhoeae strain TUM19853

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag HT079_RS11635 Protein ID WP_003690225.1
Coordinates 784..1062 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag HT079_RS11630 Protein ID WP_003690223.1
Coordinates 599..784 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HT079_RS11620 112..354 + 243 WP_003690220.1 HTH domain-containing protein -
HT079_RS11625 351..596 + 246 WP_003690221.1 hypothetical protein -
HT079_RS11630 599..784 + 186 WP_003690223.1 DUF5397 family protein Antitoxin
HT079_RS11635 784..1062 + 279 WP_003690225.1 endoribonuclease VapD Toxin
HT079_RS11640 1040..1309 - 270 WP_003692166.1 hypothetical protein -
HT079_RS11645 1341..1982 - 642 WP_003690229.1 Cryptic plasmid protein B -
HT079_RS11650 2066..2695 - 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -
HT079_RS11655 2680..2871 - 192 WP_003690218.1 plasmid mobilization relaxosome protein MobC -
HT079_RS11660 3139..3363 + 225 WP_025455920.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4207 4207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T36706 WP_003690225.1 NZ_AP023068:784-1062 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

>T36706 NZ_AP023068:784-1062 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT36706 WP_003690223.1 NZ_AP023068:599-784 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp

>AT36706 NZ_AP023068:599-784 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References