Detailed information of TA system TA036705

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1630631..1631317
• Replicon: chromosome
• Accession: NZ_AP023067
• Organism: Neisseria gonorrhoeae strain TUM19853

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: HT079_RS08435
• Protein ID: WP_003689143.1
• Coordinates: 1631135..1631317 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: HT079_RS08430
• Protein ID: WP_003691454.1
• Coordinates: 1630631..1631032 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HT079_RS08385	1626330..1626491	-	162	WP_003693867.1	hypothetical protein	-
HT079_RS08390	1626488..1626766	-	279	WP_003691529.1	hypothetical protein	-
HT079_RS08395	1626919..1627251	-	333	WP_003687946.1	hypothetical protein	-
HT079_RS08400	1627392..1627679	-	288	WP_050155496.1	hypothetical protein	-
HT079_RS08405	1627676..1628152	-	477	WP_012504141.1	hypothetical protein	-
HT079_RS08410	1628185..1628380	-	196	Protein_1615	hypothetical protein	-
HT079_RS08415	1628569..1629351	+	783	WP_003689146.1	hypothetical protein	-
HT079_RS08420	1629440..1629856	-	417	WP_003700378.1	hypothetical protein	-
HT079_RS08425	1629865..1630449	-	585	WP_003693477.1	SocA family protein	-
HT079_RS08430	1630631..1631032	-	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HT079_RS08435	1631135..1631317	-	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
HT079_RS08440	1631487..1632305	-	819	WP_172760554.1	DUF3037 domain-containing protein	-
HT079_RS08445	1632580..1633335	-	756	WP_003693472.1	LexA family transcriptional regulator	-
HT079_RS08450	1633472..1633657	+	186	WP_002238713.1	Cro/Cl family transcriptional regulator	-
HT079_RS08455	1633747..1633902	+	156	WP_003689578.1	hypothetical protein	-
HT079_RS08460	1633879..1634067	-	189	WP_003691445.1	hypothetical protein	-
HT079_RS08465	1634240..1634467	+	228	WP_003698261.1	helix-turn-helix domain-containing protein	-
HT079_RS08470	1634585..1635650	+	1066	Protein_1627	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1614270..1649205	34935

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T36705 WP_003689143.1 NZ_AP023067:c1631317-1631135 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T36705 NZ_AP023067:c1631317-1631135 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT36705 WP_003691454.1 NZ_AP023067:c1631032-1630631 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT36705 NZ_AP023067:c1631032-1630631 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATTCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2