Detailed information of TA system TA036703

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 784722..785284
• Replicon: chromosome
• Accession: NZ_AP023065
• Organism: Nitratiruptor sp. YY09-18

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: JG734_RS04340
• Protein ID: WP_201333807.1
• Coordinates: 784949..785284 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: JG734_RS04335
• Protein ID: WP_201333806.1
• Coordinates: 784722..784952 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG734_RS04320	779951..781135	+	1185	WP_201333803.1	UDP-N-acetylglucosamine 4,6-dehydratase	-
JG734_RS04325	781138..781818	+	681	WP_201333804.1	sugar transferase	-
JG734_RS04330	781822..784533	-	2712	WP_201333805.1	O-antigen ligase family protein	-
JG734_RS04335	784722..784952	+	231	WP_201333806.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
JG734_RS04340	784949..785284	+	336	WP_201333807.1	endoribonuclease MazF	Toxin
JG734_RS04345	785470..785754	+	285	WP_201333808.1	nucleotidyltransferase domain-containing protein	-
JG734_RS04350	785751..786191	+	441	WP_201333809.1	hypothetical protein	-
JG734_RS04355	786350..787660	+	1311	WP_201333810.1	ATP-binding protein	-
JG734_RS04360	787836..788981	-	1146	WP_201333811.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-106)

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12486.52 Da
• Isoelectric Point: 7.1640

>T36703 WP_201333807.1 NZ_AP023065:784949-785284 [Nitratiruptor sp. YY09-18]
MSYIPERGDIVWVELNPQKGHEQAGHRPALILSPYEYNKKVGLCIASPITSKSKGYPFEVAIAGKIQGVVLSDQVRTLDY
RARNVAFVEKVDEEVLEKVLEKLKLLLFDMG

Nucleotide

• Length: 336 bp

>T36703 NZ_AP023065:784949-785284 [Nitratiruptor sp. YY09-18]
ATGAGTTATATTCCTGAGCGTGGTGATATCGTTTGGGTCGAGCTCAATCCTCAAAAGGGACATGAACAAGCAGGGCATAG
GCCTGCATTGATTCTCTCACCATATGAATACAATAAGAAAGTTGGTCTATGTATCGCCTCTCCTATTACATCCAAAAGTA
AAGGGTATCCTTTTGAGGTAGCTATAGCTGGAAAGATTCAAGGAGTTGTGCTCTCTGATCAAGTAAGGACTCTTGATTAT
CGTGCAAGGAATGTCGCTTTTGTAGAAAAGGTCGATGAGGAAGTATTAGAAAAAGTACTTGAAAAATTGAAGTTGTTATT
GTTTGATATGGGATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8734.17 Da
• Isoelectric Point: 8.6015

>AT36703 WP_201333806.1 NZ_AP023065:784722-784952 [Nitratiruptor sp. YY09-18]
MTVKINKWGNSYGIRLSKQILKSLDLQENSEVDIEIREGKIILIPKKSLQSLLSQITPQNIHREIDFGDMQGKELL

Nucleotide

• Length: 231 bp

>AT36703 NZ_AP023065:784722-784952 [Nitratiruptor sp. YY09-18]
ATGACAGTCAAAATCAATAAATGGGGCAATAGCTATGGTATTAGACTTTCCAAACAGATATTGAAGAGTCTCGATCTTCA
AGAAAATAGCGAAGTCGATATTGAAATTAGAGAGGGGAAAATAATTCTTATTCCCAAGAAATCTTTACAATCGCTCTTAT
CACAAATAACTCCACAAAATATTCATCGTGAAATAGATTTTGGTGATATGCAAGGAAAAGAGCTGCTATGA