Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 870162..870724 Replicon chromosome
Accession NZ_AP023063
Organism Nitratiruptor sp. YY08-26

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JG738_RS04760 Protein ID WP_201338610.1
Coordinates 870389..870724 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag JG738_RS04755 Protein ID WP_201338609.1
Coordinates 870162..870392 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG738_RS04725 867248..867556 + 309 WP_201338604.1 hypothetical protein -
JG738_RS04730 867546..867971 + 426 WP_201338605.1 PIN domain-containing protein -
JG738_RS04735 868620..868832 - 213 WP_201338723.1 type II toxin-antitoxin system RelE/ParE family toxin -
JG738_RS04740 868874..869083 - 210 WP_201338606.1 ribbon-helix-helix domain-containing protein -
JG738_RS04745 869274..869645 + 372 WP_201340475.1 nucleotidyltransferase domain-containing protein -
JG738_RS04750 869599..870024 + 426 WP_201338608.1 DUF86 domain-containing protein -
JG738_RS04755 870162..870392 + 231 WP_201338609.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JG738_RS04760 870389..870724 + 336 WP_201338610.1 endoribonuclease MazF Toxin
JG738_RS04765 870951..871235 + 285 WP_201338611.1 nucleotidyltransferase domain-containing protein -
JG738_RS04770 871232..871672 + 441 WP_201338612.1 hypothetical protein -
JG738_RS04775 871832..872002 + 171 WP_201338613.1 hypothetical protein -
JG738_RS04780 871944..873014 + 1071 WP_201338614.1 ATP-binding protein -
JG738_RS04785 873142..874452 + 1311 WP_201338615.1 ATP-binding protein -
JG738_RS04790 874557..874820 - 264 WP_201338616.1 GIY-YIG nuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-107)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12485.54 Da        Isoelectric Point: 8.0067

>T36700 WP_201338610.1 NZ_AP023063:870389-870724 [Nitratiruptor sp. YY08-26]
MSYIPKRGDIVWVELNPQKGHEQAGHRPALILSPYEYNKKVGLCIASPITSKSKGYPFEVAIAGKIQGVVLSDQVRTLDY
RARNIAFVENVDEEVLEKVLEKLKLLLFDMG

Download         Length: 336 bp

>T36700 NZ_AP023063:870389-870724 [Nitratiruptor sp. YY08-26]
ATGAGTTATATTCCTAAGCGTGGTGATATCGTTTGGGTCGAGCTCAATCCTCAAAAAGGGCATGAACAAGCCGGACATAG
GCCTGCATTGATTCTCTCACCATATGAGTACAATAAGAAAGTTGGTCTATGTATCGCCTCTCCTATTACATCCAAAAGTA
AAGGGTATCCTTTTGAGGTAGCTATAGCTGGAAAGATTCAAGGAGTTGTGCTCTCTGATCAAGTAAGGACTCTTGATTAT
CGTGCAAGGAATATCGCTTTTGTAGAAAATGTCGATGAGGAAGTATTAGAAAAAGTACTGGAAAAACTGAAATTGTTATT
GTTTGATATGGGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8692.07 Da        Isoelectric Point: 8.6225

>AT36700 WP_201338609.1 NZ_AP023063:870162-870392 [Nitratiruptor sp. YY08-26]
MTVKINKWGNSYGIRLSKQILKSLNLQENSEIDIEIRDGKIILTPKKSLQSLLSQITPQNVHHEVDFGDMQGKEML

Download         Length: 231 bp

>AT36700 NZ_AP023063:870162-870392 [Nitratiruptor sp. YY08-26]
ATGACAGTCAAAATTAATAAATGGGGTAATAGCTATGGCATTAGACTTTCTAAACAGATATTGAAGAGTCTCAATCTTCA
AGAAAATAGCGAAATCGATATCGAAATTAGGGACGGGAAAATAATCCTCACTCCCAAAAAATCTTTGCAATCGCTCTTAT
CACAAATAACTCCACAAAATGTTCATCATGAAGTAGATTTTGGTGATATGCAAGGAAAAGAGATGTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References