Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 868615..869078 Replicon chromosome
Accession NZ_AP023059
Organism Nitratiruptor sp. YY08-13

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JG736_RS04725 Protein ID WP_201338723.1
Coordinates 868615..868827 (-) Length 71 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag JG736_RS04730 Protein ID WP_201338606.1
Coordinates 868869..869078 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG736_RS04705 863737..864429 + 693 WP_201338602.1 WecB/TagA/CpsF family glycosyltransferase -
JG736_RS04710 864412..867132 - 2721 WP_201338603.1 O-antigen ligase family protein -
JG736_RS04715 867243..867551 + 309 WP_201338604.1 hypothetical protein -
JG736_RS04720 867541..867966 + 426 WP_201338605.1 PIN domain-containing protein -
JG736_RS04725 868615..868827 - 213 WP_201338723.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JG736_RS04730 868869..869078 - 210 WP_201338606.1 ribbon-helix-helix domain-containing protein Antitoxin
JG736_RS04735 869248..869640 + 393 WP_201338607.1 nucleotidyltransferase domain-containing protein -
JG736_RS04740 869594..870019 + 426 WP_201338608.1 DUF86 domain-containing protein -
JG736_RS04745 870157..870387 + 231 WP_201338609.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JG736_RS04750 870384..870719 + 336 WP_201338610.1 endoribonuclease MazF -
JG736_RS04755 870946..871230 + 285 WP_201338611.1 nucleotidyltransferase domain-containing protein -
JG736_RS04760 871227..871667 + 441 WP_201338612.1 hypothetical protein -
JG736_RS04765 871827..871997 + 171 WP_201338613.1 hypothetical protein -
JG736_RS04770 871939..873009 + 1071 WP_201338614.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-67)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8338.66 Da        Isoelectric Point: 9.2779

>T36695 WP_201338723.1 NZ_AP023059:c868827-868615 [Nitratiruptor sp. YY08-13]
INKKDQIKIIDTIENRLAINPYSGKKLAGSLSDFYRYRVEKYHIIYSIHESNIEIEIIKIGHRKDIYDLM

Download         Length: 213 bp

>T36695 NZ_AP023059:c868827-868615 [Nitratiruptor sp. YY08-13]
ATAAATAAAAAAGATCAGATTAAAATTATCGATACTATCGAAAATAGGCTCGCCATCAATCCCTATTCTGGGAAAAAATT
AGCCGGTAGTCTTTCTGATTTTTATAGATATCGTGTGGAAAAATATCATATAATTTATAGTATTCATGAATCAAATATAG
AAATAGAAATTATAAAGATCGGACATAGGAAAGATATTTACGATTTGATGTAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8196.58 Da        Isoelectric Point: 4.8896

>AT36695 WP_201338606.1 NZ_AP023059:c869078-868869 [Nitratiruptor sp. YY08-13]
MLTVRLDKELEQKLEKLAILTKRPKSFFVKEALRQYLEDIEDILDAKERVNDPAKELITLDELKRELNV

Download         Length: 210 bp

>AT36695 NZ_AP023059:c869078-868869 [Nitratiruptor sp. YY08-13]
ATGCTTACCGTTCGACTCGATAAAGAACTTGAACAAAAGTTAGAAAAATTAGCCATTTTGACCAAGCGGCCAAAAAGTTT
TTTTGTCAAAGAAGCACTTCGCCAATATCTCGAAGATATTGAGGATATCTTAGACGCTAAAGAAAGAGTAAACGATCCAG
CAAAAGAACTCATTACTTTAGATGAGCTCAAAAGAGAACTGAATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References