Detailed information of TA system TA036694

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 5318..5953
• Replicon: plasmid pC4V358
• Accession: NZ_AP023056
• Organism: Thaumasiovibrio subtropicus strain C4V358

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: TSUB_RS24840
• Protein ID: WP_087019235.1
• Coordinates: 5774..5953 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: TSUB_RS24835
• Protein ID: WP_087019232.1
• Coordinates: 5318..5734 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TSUB_RS24820	1788..2273	+	486	WP_159064874.1	hypothetical protein	-
TSUB_RS24825	2338..3183	+	846	WP_087019223.1	ParA family protein	-
TSUB_RS24830	3280..4206	+	927	WP_087019226.1	ParB/RepB/Spo0J family partition protein	-
TSUB_RS24835	5318..5734	-	417	WP_087019232.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
TSUB_RS24840	5774..5953	-	180	WP_087019235.1	type II toxin-antitoxin system HicA family toxin	Toxin
TSUB_RS24845	6065..6343	-	279	WP_159064875.1	hypothetical protein	-
TSUB_RS24850	6610..6987	-	378	WP_087019238.1	hypothetical protein	-
TSUB_RS24855	7022..7738	-	717	WP_087019241.1	StbB family protein	-
TSUB_RS24860	7735..8202	-	468	WP_087019244.1	hypothetical protein	-
TSUB_RS24865	8510..8854	+	345	WP_087019247.1	relaxosome protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..35361	35361

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-116)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6581.87 Da
• Isoelectric Point: 10.9659

>T36694 WP_087019235.1 NZ_AP023056:c5953-5774 [Thaumasiovibrio subtropicus]
VKSRDLIKEVEAAGWVLVRVKGSHHQFKHPDHKLPLTIPHPKKDLGMGLVKAIKKQAGL

Nucleotide

• Length: 180 bp

>T36694 NZ_AP023056:c5953-5774 [Thaumasiovibrio subtropicus]
GTGAAAAGCAGAGACTTAATTAAAGAGGTGGAAGCGGCTGGTTGGGTTCTGGTGAGAGTGAAAGGAAGTCATCACCAATT
CAAACATCCAGACCACAAATTACCTCTCACGATTCCACATCCGAAAAAGGACTTGGGTATGGGACTTGTGAAAGCAATTA
AAAAACAGGCGGGGCTTTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15325.09 Da
• Isoelectric Point: 4.2195

>AT36694 WP_087019232.1 NZ_AP023056:c5734-5318 [Thaumasiovibrio subtropicus]
MLYPIAIEAGDDNTAFGVVFPDAAGCFAAGDSYEDALVQAKEALEFYFETLAEDGEVPPLASSVNDHFDKEEFNGWVWAL
VDIDLESFLGKSRKYNVSLPTLLRKKIDDAVDEHKHYGGFSQFVQEAIVKELARSKGR

Nucleotide

• Length: 417 bp

>AT36694 NZ_AP023056:c5734-5318 [Thaumasiovibrio subtropicus]
ATGCTATATCCAATTGCTATCGAAGCAGGAGACGACAATACCGCTTTTGGCGTTGTATTCCCTGATGCTGCTGGCTGCTT
TGCGGCAGGTGACAGCTATGAAGATGCTTTAGTGCAAGCGAAAGAGGCGCTAGAGTTTTATTTTGAAACGCTTGCCGAAG
ATGGAGAAGTTCCGCCACTGGCAAGCAGTGTTAACGATCACTTTGACAAAGAAGAATTTAATGGCTGGGTGTGGGCGCTT
GTCGATATAGACCTTGAATCCTTCTTAGGAAAATCCAGAAAGTACAACGTATCATTGCCCACACTGTTGCGGAAAAAAAT
CGATGATGCGGTTGATGAACACAAGCATTACGGTGGTTTTTCGCAGTTCGTCCAAGAAGCCATTGTAAAAGAACTAGCGC
GCTCAAAAGGGCGCTAG