Detailed information of TA system TA036693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 1537597..1538615
• Replicon: chromosome
• Accession: NZ_AP023055
• Organism: Thaumasiovibrio subtropicus strain C4V358

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: TSUB_RS23200
• Protein ID: WP_246616486.1
• Coordinates: 1537597..1538163 (-)
• Length: 189 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: TSUB_RS23205
• Protein ID: WP_087019634.1
• Coordinates: 1538166..1538615 (-)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TSUB_RS23170	1533409..1534290	-	882	WP_087019651.1	NAD(P)-dependent oxidoreductase	-
TSUB_RS23175	1534475..1535164	-	690	WP_087019648.1	hypothetical protein	-
TSUB_RS23180	1535168..1535392	-	225	WP_087019646.1	DUF6500 family protein	-
TSUB_RS23185	1535795..1535953	+	159	WP_192867837.1	hypothetical protein	-
TSUB_RS23190	1535943..1536539	+	597	WP_087019643.1	Fic family protein	-
TSUB_RS23195	1536744..1537283	-	540	WP_087019640.1	ClbS/DfsB family four-helix bundle protein	-
TSUB_RS23200	1537597..1538163	-	567	WP_246616486.1	PIN domain-containing protein	Toxin
TSUB_RS23205	1538166..1538615	-	450	WP_087019634.1	excisionase family DNA-binding protein	Antitoxin
TSUB_RS23210	1538954..1541572	-	2619	WP_159064881.1	glycoside hydrolase family 3 C-terminal domain-containing protein	-
TSUB_RS23215	1541693..1543348	-	1656	WP_087019629.1	sulfatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-112)

Antitoxin

• SinI-like, DNA-binding domain (79-126)

Sequences

Toxin

Protein

• Length: 189 a.a.
• Molecular weight: 21365.75 Da
• Isoelectric Point: 6.0946

>T36693 WP_246616486.1 NZ_AP023055:c1538163-1537597 [Thaumasiovibrio subtropicus]
VAYTVILDACVMYPAPLRSYLMYLANTGLFKARWTDRIHDEWMRNLVANNPSIDPQKLERTRQLMNANVPYCLVEGYEPL
IEGLTLPDQDDRHVVAAALKGQAEAIITFNLKDFPTTQLDALGLSAIHPDEFLSDMFELKPSACITAAHQQRQGLKRPPL
SAAEFLECLQKQRLPSFVSRLKQFEMML

Nucleotide

• Length: 567 bp

>T36693 NZ_AP023055:c1538163-1537597 [Thaumasiovibrio subtropicus]
GTGGCGTATACTGTAATACTGGATGCATGCGTTATGTATCCGGCACCTCTTCGCAGTTACCTGATGTACCTTGCCAATAC
TGGTTTGTTCAAAGCTCGCTGGACTGACCGAATCCACGATGAATGGATGCGTAACCTTGTTGCCAACAACCCAAGCATCG
ATCCACAAAAACTTGAGCGGACTCGACAGCTAATGAATGCAAACGTACCATACTGCTTGGTTGAAGGATATGAACCATTG
ATTGAAGGCTTAACGCTGCCTGATCAAGACGATAGACATGTTGTAGCGGCAGCTCTCAAAGGGCAAGCAGAGGCTATTAT
TACGTTCAATCTAAAGGATTTTCCTACGACTCAGCTTGATGCGCTTGGTCTATCTGCTATTCATCCTGATGAATTTTTGA
GTGATATGTTTGAACTCAAACCAAGTGCTTGTATTACGGCGGCGCACCAACAGCGACAAGGACTTAAACGCCCACCATTG
TCTGCCGCTGAGTTTTTAGAATGTCTGCAAAAACAACGCCTGCCCAGTTTTGTCTCGCGGTTAAAGCAGTTTGAGATGAT
GCTTTGA

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16247.69 Da
• Isoelectric Point: 4.9108

>AT36693 WP_087019634.1 NZ_AP023055:c1538615-1538166 [Thaumasiovibrio subtropicus]
MITTTLPSAEEMALARLSSQELSAVIESSGAAQQISVVDKSGKIHEVTLPASALKMMLEVLTQLGNGNSVNITPIHAELT
TQEGADLLNMSRPTFIKLLDTGTIPYSRIGNRRKVQFAAVMAYKQQLEVQRLKTLDELSALDQELDMGY

Nucleotide

• Length: 450 bp

>AT36693 NZ_AP023055:c1538615-1538166 [Thaumasiovibrio subtropicus]
ATGATCACCACAACGTTGCCTAGTGCAGAAGAAATGGCTTTGGCAAGACTCAGCAGCCAAGAACTGTCTGCGGTTATTGA
GAGTAGCGGCGCCGCTCAACAGATCAGCGTCGTTGATAAATCGGGGAAAATTCACGAGGTTACTTTGCCTGCCAGTGCAT
TGAAGATGATGCTGGAAGTGTTAACGCAATTGGGAAACGGTAATTCGGTTAATATTACCCCCATCCATGCAGAGCTGACG
ACTCAGGAAGGCGCAGACTTGCTGAACATGTCTCGTCCAACGTTCATCAAGTTGCTTGACACTGGAACGATCCCTTACAG
CCGGATTGGCAATCGGCGTAAAGTTCAGTTTGCTGCCGTCATGGCTTACAAGCAGCAACTAGAAGTCCAACGACTTAAAA
CGTTGGATGAGCTGTCTGCATTAGATCAAGAGCTGGATATGGGATACTAA