Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1216920..1217568 Replicon chromosome
Accession NZ_AP023055
Organism Thaumasiovibrio subtropicus strain C4V358

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag TSUB_RS21950 Protein ID WP_246616476.1
Coordinates 1216920..1217342 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag TSUB_RS21955 Protein ID WP_087025062.1
Coordinates 1217335..1217568 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TSUB_RS21935 1212655..1213680 - 1026 WP_087025070.1 hypothetical protein -
TSUB_RS21940 1214120..1214896 + 777 WP_087025068.1 DeoR family transcriptional regulator -
TSUB_RS21945 1214908..1216740 + 1833 WP_087025066.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
TSUB_RS21950 1216920..1217342 - 423 WP_246616476.1 type II toxin-antitoxin system VapC family toxin Toxin
TSUB_RS21955 1217335..1217568 - 234 WP_087025062.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TSUB_RS21960 1217775..1218925 + 1151 WP_087022304.1 IS3 family transposase -
TSUB_RS21965 1219105..1219557 + 453 WP_087022307.1 hypothetical protein -
TSUB_RS21970 1219594..1219809 + 216 WP_087022309.1 hypothetical protein -
TSUB_RS21975 1219986..1220309 + 324 WP_087022312.1 hypothetical protein -
TSUB_RS21980 1220625..1221053 + 429 WP_087022314.1 GNAT family N-acetyltransferase -
TSUB_RS21985 1221126..1221674 + 549 WP_087022316.1 DinB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1218101..1218925 824


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-131)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15723.29 Da        Isoelectric Point: 7.8012

>T36692 WP_246616476.1 NZ_AP023055:c1217342-1216920 [Thaumasiovibrio subtropicus]
MNKKINYMLDTCICSFIMREQPIELLQKLQAVVGKQHRIVISTITYQEMQYGLLGKKASPKHAVLVEEFLKRVDEILPWD
KAAVDATTEVKRDLMAKGTPIGNNDTAIAGHAIATGCVVVTNNTREFNRVTGLNLEDWVH

Download         Length: 423 bp

>T36692 NZ_AP023055:c1217342-1216920 [Thaumasiovibrio subtropicus]
TTGAATAAAAAGATCAACTACATGCTCGATACTTGTATCTGCTCATTCATTATGAGAGAGCAACCAATTGAGCTTTTACA
AAAGCTCCAAGCAGTTGTTGGTAAGCAACATAGAATTGTGATTTCGACTATCACCTACCAAGAAATGCAATACGGGTTAC
TTGGTAAAAAAGCGTCTCCTAAACATGCGGTACTTGTAGAAGAATTTCTTAAGCGAGTTGATGAGATATTACCTTGGGAT
AAAGCAGCAGTAGACGCCACTACAGAAGTTAAGCGCGACCTAATGGCAAAAGGTACACCTATCGGCAATAACGATACGGC
TATCGCGGGACACGCAATTGCAACAGGCTGTGTTGTTGTTACTAACAACACAAGAGAGTTTAATCGAGTTACTGGTTTAA
ACCTCGAAGATTGGGTTCATTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8947.97 Da        Isoelectric Point: 4.5370

>AT36692 WP_087025062.1 NZ_AP023055:c1217568-1217335 [Thaumasiovibrio subtropicus]
MRTVSIFKNGKNQAVRLPKEFEFDGVNELEIHKEGDVITLRPARPDWLSFGEQDKADKDFMASREDVVTDEGRFNFE

Download         Length: 234 bp

>AT36692 NZ_AP023055:c1217568-1217335 [Thaumasiovibrio subtropicus]
ATGAGAACGGTATCAATATTTAAAAATGGCAAGAATCAAGCGGTTCGTTTGCCTAAAGAGTTTGAGTTCGATGGTGTGAA
CGAACTAGAAATTCACAAAGAAGGCGATGTAATCACTTTGCGCCCAGCTCGCCCTGATTGGCTGTCGTTCGGGGAGCAAG
ATAAAGCTGATAAAGACTTTATGGCCAGCCGTGAAGATGTAGTGACAGACGAAGGGCGATTTAACTTTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References