Detailed information of TA system TA036678

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2155418..2155947
• Replicon: chromosome
• Accession: NZ_AP023034
• Organism: Staphylococcus aureus strain TPS3156

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HZ307_RS10760
• Protein ID: WP_000621175.1
• Coordinates: 2155418..2155780 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: HZ307_RS10765
• Protein ID: WP_000948331.1
• Coordinates: 2155777..2155947 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZ307_RS10740	2152396..2153166	-	771	WP_001041103.1	RNA polymerase sigma factor SigB	-
HZ307_RS10745	2153141..2153620	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
HZ307_RS10750	2153622..2153948	-	327	WP_001052491.1	anti-sigma factor antagonist	-
HZ307_RS10755	2154067..2155068	-	1002	WP_178890286.1	PP2C family protein-serine/threonine phosphatase	-
HZ307_RS10760	2155418..2155780	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HZ307_RS10765	2155777..2155947	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
HZ307_RS10770	2156032..2157180	-	1149	WP_001281145.1	alanine racemase	-
HZ307_RS10775	2157246..2157605	-	360	WP_000581200.1	holo-ACP synthase	-
HZ307_RS10780	2157609..2158100	-	492	WP_001205910.1	PH domain-containing protein	-
HZ307_RS10785	2158087..2159670	-	1584	WP_001294626.1	PH domain-containing protein	-
HZ307_RS10790	2159663..2160142	-	480	WP_001287088.1	hypothetical protein	-
HZ307_RS10795	2160350..2160910	-	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T36678 WP_000621175.1 NZ_AP023034:c2155780-2155418 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T36678 NZ_AP023034:c2155780-2155418 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT36678 WP_000948331.1 NZ_AP023034:c2155947-2155777 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT36678 NZ_AP023034:c2155947-2155777 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1