Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 864197..864674 Replicon chromosome
Accession NZ_AP023034
Organism Staphylococcus aureus strain TPS3156

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag HZ307_RS04135 Protein ID WP_000052078.1
Coordinates 864197..864385 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag HZ307_RS04140 Protein ID WP_001059690.1
Coordinates 864414..864674 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ307_RS04105 860238..860708 + 471 WP_000824472.1 hypothetical protein -
HZ307_RS04110 861049..861735 + 687 WP_001548082.1 thermonuclease family protein -
HZ307_RS04115 862092..862292 + 201 WP_001059082.1 cold-shock protein -
HZ307_RS04120 862788..863006 - 219 WP_000005886.1 hypothetical protein -
HZ307_RS04125 863068..863352 - 285 WP_001004395.1 hypothetical protein -
HZ307_RS04130 863440..864009 - 570 WP_001106654.1 hypothetical protein -
HZ307_RS04135 864197..864385 - 189 WP_000052078.1 hypothetical protein Toxin
HZ307_RS04140 864414..864674 - 261 WP_001059690.1 hypothetical protein Antitoxin
HZ307_RS04145 865015..865218 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
HZ307_RS04150 865215..865451 - 237 WP_000368687.1 hypothetical protein -
HZ307_RS04155 865676..866257 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
HZ307_RS04160 866330..866947 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
HZ307_RS04165 867102..867596 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
HZ307_RS04170 867995..868417 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
HZ307_RS04175 868565..869281 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-90)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T36670 WP_000052078.1 NZ_AP023034:c864385-864197 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T36670 NZ_AP023034:c864385-864197 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT36670 WP_001059690.1 NZ_AP023034:c864674-864414 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT36670 NZ_AP023034:c864674-864414 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References