Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /SpoIISA(toxin) |
| Location | 2467923..2468898 | Replicon | chromosome |
| Accession | NZ_AP022986 | ||
| Organism | Bacillus cereus strain 30052 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | L6499_RS12665 | Protein ID | WP_052494343.1 |
| Coordinates | 2467923..2468660 (+) | Length | 246 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | C2VTW9 |
| Locus tag | L6499_RS12670 | Protein ID | WP_000588936.1 |
| Coordinates | 2468773..2468898 (+) | Length | 42 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L6499_RS12640 (BC30052_2485) | 2463434..2464135 | + | 702 | WP_001294994.1 | hypothetical protein | - |
| L6499_RS12645 (BC30052_2486) | 2464254..2465138 | + | 885 | WP_042512702.1 | hypothetical protein | - |
| L6499_RS12650 (BC30052_2487) | 2465458..2466240 | - | 783 | Protein_2418 | thiamine pyrophosphate-binding protein | - |
| L6499_RS12655 (BC30052_2488) | 2466347..2466829 | + | 483 | WP_042512701.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| L6499_RS12660 (BC30052_2489) | 2466997..2467734 | + | 738 | WP_042512700.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
| L6499_RS12665 (BC30052_2490) | 2467923..2468660 | + | 738 | WP_052494343.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
| L6499_RS12670 (BC30052_2491) | 2468773..2468898 | + | 126 | WP_000588936.1 | hypothetical protein | Antitoxin |
| L6499_RS12675 (BC30052_2492) | 2468975..2469136 | + | 162 | WP_236805588.1 | hypothetical protein | - |
| L6499_RS12680 (BC30052_2493) | 2469187..2469372 | - | 186 | WP_002052863.1 | hypothetical protein | - |
| L6499_RS30580 (BC30052_2494) | 2469690..2469824 | + | 135 | WP_272884478.1 | hypothetical protein | - |
| L6499_RS12685 (BC30052_2495) | 2469901..2470077 | + | 177 | WP_042512697.1 | stage II sporulation protein SB | - |
| L6499_RS12690 (BC30052_2496) | 2470221..2471690 | + | 1470 | WP_042512696.1 | beta-Ala-His dipeptidase | - |
| L6499_RS12695 (BC30052_2497) | 2472271..2472741 | - | 471 | WP_000670597.1 | DUF5065 family protein | - |
| L6499_RS12700 (BC30052_2498) | 2472917..2473537 | + | 621 | WP_127813147.1 | SGNH/GDSL hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28358.10 Da Isoelectric Point: 8.9957
>T36665 WP_052494343.1 NZ_AP022986:2467923-2468660 [Bacillus cereus]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYKKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYKKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T36665 NZ_AP022986:2467923-2468660 [Bacillus cereus]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATTGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCGAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACAGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATACAAAAAAAGCTTAAACGCATTTTTAGATTCATACGGGGAAAAGATTGGAGCGAAAATT
GTTGTATTTGAAGCGGCAAAAGAATTAAATACAAACTTTCGCGGTATCCGTTCTCAATTTAGTACCATTATTCCATTAGA
GTACATTGAGCAATTGAATGAGCAGAAAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATTGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCGAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACAGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATACAAAAAAAGCTTAAACGCATTTTTAGATTCATACGGGGAAAAGATTGGAGCGAAAATT
GTTGTATTTGAAGCGGCAAAAGAATTAAATACAAACTTTCGCGGTATCCGTTCTCAATTTAGTACCATTATTCCATTAGA
GTACATTGAGCAATTGAATGAGCAGAAAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA
Antitoxin
Download Length: 42 a.a. Molecular weight: 4888.29 Da Isoelectric Point: 3.9798
>AT36665 WP_000588936.1 NZ_AP022986:2468773-2468898 [Bacillus cereus]
VIKENNNDFFKEDNEDTTDFSLIKGDTLQQVEELEDELKRK
VIKENNNDFFKEDNEDTTDFSLIKGDTLQQVEELEDELKRK
Download Length: 126 bp
>AT36665 NZ_AP022986:2468773-2468898 [Bacillus cereus]
GTGATAAAAGAGAATAACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAATTAGAAGATGAATTAAAAAGAAAATGA
GTGATAAAAGAGAATAACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
TTTGCAGCAAGTAGAAGAATTAGAAGATGAATTAAAAAGAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|