Detailed information of TA system TA036661

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2392010..2392985
• Replicon: chromosome
• Accession: NZ_AP022978
• Organism: Bacillus cereus strain 30043

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: L6436_RS12285
• Protein ID: WP_062923173.1
• Coordinates: 2392010..2392747 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: L6436_RS12290
• Protein ID: WP_062923165.1
• Coordinates: 2392860..2392985 (+)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6436_RS12260 (BC30043_2382)	2387506..2388207	+	702	WP_236788434.1	hypothetical protein	-
L6436_RS12265 (BC30043_2383)	2388333..2389217	+	885	WP_062923162.1	hypothetical protein	-
L6436_RS12270	2389526..2390328	-	803	Protein_2342	thiamine pyrophosphate-binding protein	-
L6436_RS12275 (BC30043_2386)	2390435..2390917	+	483	WP_062923163.1	MarR family winged helix-turn-helix transcriptional regulator	-
L6436_RS12280 (BC30043_2387)	2391084..2391821	+	738	WP_062923164.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
L6436_RS12285 (BC30043_2388)	2392010..2392747	+	738	WP_062923173.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
L6436_RS12290 (BC30043_2389)	2392860..2392985	+	126	WP_062923165.1	hypothetical protein	Antitoxin
L6436_RS27985	2393059..2393234	+	176	Protein_2347	stage II sporulation protein SB	-
L6436_RS12295 (BC30043_2390)	2393253..2393642	-	390	WP_062923167.1	YxeA family protein	-
L6436_RS12300 (BC30043_2391)	2393859..2395328	+	1470	WP_062923168.1	beta-Ala-His dipeptidase	-
L6436_RS12305 (BC30043_2392)	2395910..2396380	-	471	WP_061530815.1	DUF5065 family protein	-
L6436_RS12310 (BC30043_2393)	2396834..2397481	+	648	WP_236798344.1	CatB-related O-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (9-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28351.03 Da
• Isoelectric Point: 8.3034

>T36661 WP_062923173.1 NZ_AP022978:2392010-2392747 [Bacillus cereus]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYIKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPFEHIEQLNEQKAVQVENVGIIPAKTVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T36661 NZ_AP022978:2392010-2392747 [Bacillus cereus]
GTGATCTCTAACATTCGAATCGGTTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAGTTGTACGAAGAGAAGAAGCAACGGATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTCAATCCGGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAAGAATATATAAAAAGCTTAAACGCATTTTTAGATTCGTATGGTGAAAAGATTGGGGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGCGGTATCCGCTCACAATTTAGTATCATCGTTCCGTTTGA
ACATATTGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCGGCAAAAACTGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAATCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4938.34 Da
• Isoelectric Point: 3.9150

>AT36661 WP_062923165.1 NZ_AP022978:2392860-2392985 [Bacillus cereus]
VIKDYDNDFFKEENEDTTDFSLIKGDTLQQVEELEDELKRK

Nucleotide

• Length: 126 bp

>AT36661 NZ_AP022978:2392860-2392985 [Bacillus cereus]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGAAAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGATGAATTAAAAAGAAAATGA